Jung-Su Chang1, Shiue-Ming Lin2, Jane C-J Chao1, Yi-Chun Chen1, Chi-Mei Wang1, Ni-Hsin Chou1, Wen-Harn Pan3, Chyi-Huey Bai2. 1. 1School of Nutrition and Health Sciences,Taipei Medical University,Taipei City,Taiwan, Republic ofChina. 2. 2Department of Public Health,College of Medicine,Taipei Medical University,250 Wu-Hsing Street,Taipei City,Taiwan 110, Republic ofChina. 3. 3Institute of Biomedical Science,Academia Sinica,Nankang,Taipei,Taiwan, Republic ofChina.
Abstract
OBJECTIVES: Asians and Pacific Islanders have higher circulating serum ferritin (SF) compared with Caucasians but the clinical significance of this is unclear. There is a higher prevalence of metabolic syndrome (MetS) in Taiwanese Indigenous than Han Chinese. Genetically, Indigenous are related to Austronesians and account for 2 % of Taiwan's population. We tested the hypothesis that accumulation of Fe in the body contributes to the ethnic/racial disparities in MetS in Taiwan. DESIGN: A population-based, cross-sectional study. SETTING: National Nutrition and Health Survey in Taiwan and Penghu Island. SUBJECTS: A total of 2638 healthy adults aged ≥19 years. Three ethnic groups were included. RESULTS: Han Chinese and Indigenous people had comparable levels of SF. Austronesia origin was independently associated with MetS (OR = 2·61, 95 % CI 2·02, 3·36). After multiple adjustments, the odds for MetS (OR = 2·49, 95 % CI 1·15, 5·28) was significantly higher among Indigenous people in the highest SF tertile compared with those in the lowest tertile. Hakka and Penghu Islanders yielded the lowest risks (OR = 1·08, 95 % CI 0·44, 2·65 and OR = 1·21, 95 % CI 0·52, 2·78, respectively). Indigenous people in the highest SF tertile had increased risk for abnormal levels of fasting glucose (OR = 2·34, 95 % CI 1·27, 4·29), TAG (OR = 1·94, 95 % CI 1·11, 3·39) and HDL-cholesterol (OR = 2·10, 95 % CI 1·18, 3·73) than those in the lowest SF tertile. CONCLUSIONS: Our results raise the possibility that ethnic/racial differences in body Fe store susceptibility may contribute to racial and geographic disparities in MetS.
OBJECTIVES: Asians and Pacific Islanders have higher circulating serum ferritin (SF) compared with Caucasians but the clinical significance of this is unclear. There is a higher prevalence of metabolic syndrome (MetS) in Taiwanese Indigenous than Han Chinese. Genetically, Indigenous are related to Austronesians and account for 2 % of Taiwan's population. We tested the hypothesis that accumulation of Fe in the body contributes to the ethnic/racial disparities in MetS in Taiwan. DESIGN: A population-based, cross-sectional study. SETTING: National Nutrition and Health Survey in Taiwan and Penghu Island. SUBJECTS: A total of 2638 healthy adults aged ≥19 years. Three ethnic groups were included. RESULTS: Han Chinese and Indigenous people had comparable levels of SF. Austronesia origin was independently associated with MetS (OR = 2·61, 95 % CI 2·02, 3·36). After multiple adjustments, the odds for MetS (OR = 2·49, 95 % CI 1·15, 5·28) was significantly higher among Indigenous people in the highest SF tertile compared with those in the lowest tertile. Hakka and Penghu Islanders yielded the lowest risks (OR = 1·08, 95 % CI 0·44, 2·65 and OR = 1·21, 95 % CI 0·52, 2·78, respectively). Indigenous people in the highest SF tertile had increased risk for abnormal levels of fasting glucose (OR = 2·34, 95 % CI 1·27, 4·29), TAG (OR = 1·94, 95 % CI 1·11, 3·39) and HDL-cholesterol (OR = 2·10, 95 % CI 1·18, 3·73) than those in the lowest SF tertile. CONCLUSIONS: Our results raise the possibility that ethnic/racial differences in body Fe store susceptibility may contribute to racial and geographic disparities in MetS.