Literature DB >> 2386490

Age-related changes in glutathione synthesis in the eye lens.

J V Ferrer1, E Gascó, J Sastre, F V Pallardó, M Asensi, J Viña.   

Abstract

Eye lenses from young rats or mice synthesize GSH from methionine or N-acetylcysteine. However, lenses from old animals do not synthesize GSH from methionine. This is due to the absence of cystathionase activity in old lenses. GSH monoethyl ester, but not free GSH, increases GSH content and protects the lens against experimental oxidative stress. The importance of these results in the prevention of cataractogenesis is discussed.

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Year:  1990        PMID： 2386490      PMCID： PMC1131610          DOI： 10.1042/bj2690531

Source DB:  PubMed          Journal:  Biochem J        ISSN： 0264-6021            Impact factor:   3.857


  22 in total

1.  Glutathione ester prevents buthionine sulfoximine-induced cataracts and lens epithelial cell damage.

Authors:  J Mårtensson; R Steinherz; A Jain; A Meister
Journal:  Proc Natl Acad Sci U S A       Date:  1989-11       Impact factor: 11.205

2.  Studies on the crystalline lens. II. Synthesis of glutathione in the normal and cataractous rabbit lens.

Authors:  V E KINSEY; F C MERRIAM
Journal:  AMA Arch Ophthalmol       Date:  1950-09

3.  The role of methionine in glutathione biosynthesis by isolated hepatocytes.

Authors:  D J Reed; S Orrenius
Journal:  Biochem Biophys Res Commun       Date:  1977-08-22       Impact factor: 3.575

4.  The fate of extracellular glutathione in the rat.

Authors:  R Hahn; A Wendel; L Flohé
Journal:  Biochim Biophys Acta       Date:  1978-03-20

5.  Microsomal lipid peroxidation.

Authors:  J A Buege; S D Aust
Journal:  Methods Enzymol       Date:  1978       Impact factor: 1.600

6.  Potent and specific inhibition of glutathione synthesis by buthionine sulfoximine (S-n-butyl homocysteine sulfoximine).

Authors:  O W Griffith; A Meister
Journal:  J Biol Chem       Date:  1979-08-25       Impact factor: 5.157

Review 7.  Protein oxidation and loss of protease activity may lead to cataract formation in the aged lens.

Authors:  A Taylor; K J Davies
Journal:  Free Radic Biol Med       Date:  1987       Impact factor: 7.376

8.  Maintenance of glutathione content is isolated hepatocyctes.

Authors:  J Viña; R Hems; H A Krebs
Journal:  Biochem J       Date:  1978-03-15       Impact factor: 3.857

9.  Effect of aging on aqueous-phase antioxidants in tissues of male Fischer rats.

Authors:  L E Rikans; D R Moore
Journal:  Biochim Biophys Acta       Date:  1988-09-08

10.  Glutathione levels in human lens: regional distribution in different forms of cataract.

Authors:  H Pau; P Graf; H Sies
Journal:  Exp Eye Res       Date:  1990-01       Impact factor: 3.467
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  3 in total

1.  Cystathionine gamma-Lyase-deficient mice require dietary cysteine to protect against acute lethal myopathy and oxidative injury.

Authors:  Isao Ishii; Noriyuki Akahoshi; Hidenori Yamada; Shintaro Nakano; Takashi Izumi; Makoto Suematsu
Journal:  J Biol Chem       Date:  2010-06-21       Impact factor: 5.157

Review 2.  Physiological Mechanisms Regulating Lens Transport.

Authors:  Adrienne A Giannone; Leping Li; Caterina Sellitto; Thomas W White
Journal:  Front Physiol       Date:  2021-12-23       Impact factor: 4.566

3.  Effects of N-acetylcysteine and glutathione ethyl ester drops on streptozotocin-induced diabetic cataract in rats.

Authors:  Shu Zhang; Fei-Yan Chai; Hong Yan; Yong Guo; J J Harding
Journal:  Mol Vis       Date:  2008-05-12       Impact factor: 2.367
  3 in total

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