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Literature DB >> 2386488

Evidence for two Ca2(+)-mobilizing purinoceptors on rat hepatocytes.

C J Dixon¹, N M Woods, K S Cuthbertson, P H Cobbold.

Abstract

Aequorin measurements of cytosolic free Ca2+ in single rat hepatocytes show that ADP and ATP, thought to act through the same P2Y purinoceptor, elicited very different responses in the majority of cells tested. ADP invariably induced transients of short duration (approx. 9 s), whereas ATP induced either similar transients or transients with a much longer duration (approx. 49 s). We explain this variability in terms of two separate purinoceptors on rat hepatocytes, one of which responds to either ATP or ADP to generate free-Ca2+ transients of short duration, and the other responds to ATP only, with transients of longer duration.

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Year: 1990 PMID： 2386488 PMCID： PMC1131604 DOI： 10.1042/bj2690499

Source DB: PubMed Journal: Biochem J ISSN： 0264-6021 Impact factor: 3.857

18 in total

Review 1. Spatial and temporal aspects of cell signalling.

Authors: M J Berridge; P H Cobbold; K S Cuthbertson
Journal: Philos Trans R Soc Lond B Biol Sci Date: 1988-07-26 Impact factor: 6.237

2. Modulation of free Ca oscillations in single hepatocytes by changes in extracellular K+, Na+ and Ca2+.

Authors: N M Woods; C J Dixon; K S Cuthbertson; P H Cobbold
Journal: Cell Calcium Date: 1990-05 Impact factor: 6.817

3. P2-purinergic receptors are coupled to two signal transduction systems leading to inhibition of cAMP generation and to production of inositol trisphosphate in rat hepatocytes.

Authors: F Okajima; Y Tokumitsu; Y Kondo; M Ui
Journal: J Biol Chem Date: 1987-10-05 Impact factor: 5.157

Review 4. Calcium oscillations in non-excitable cells.

Authors: T J Rink; R Jacob
Journal: Trends Neurosci Date: 1989-02 Impact factor: 13.837

5. Single cell measurements in research on calcium-mobilising purinoceptors.

Authors: P Cobbold; N Woods; J Wainwright; R Cuthbertson
Journal: J Recept Res Date: 1988

6. Two distinct receptors for ATP can be distinguished in Swiss 3T6 mouse fibroblasts by their desensitization.

Authors: F A Gonzalez; E Bonapace; I Belzer; I Friedberg; L A Heppel
Journal: Biochem Biophys Res Commun Date: 1989-10-31 Impact factor: 3.575

7. Extracellular ATP induces the release of calcium from intracellular stores without the activation of protein kinase C in Swiss 3T6 mouse fibroblasts.

Authors: F A Gonzalez; E Rozengurt; L A Heppel
Journal: Proc Natl Acad Sci U S A Date: 1989-06 Impact factor: 11.205

8. Purification of (Ca2+-Mg2+)-ATPase from rat liver plasma membranes.

Authors: S H Lin; J N Fain
Journal: J Biol Chem Date: 1984-03-10 Impact factor: 5.157

9. ATP-induced calcium mobilization in human neutrophils.

Authors: M Kuroki; K Takeshige; S Minakami
Journal: Biochim Biophys Acta Date: 1989-06-15

10. Characterization of cytosolic calcium oscillations induced by phenylephrine and vasopressin in single fura-2-loaded hepatocytes.

Authors: T A Rooney; E J Sass; A P Thomas
Journal: J Biol Chem Date: 1989-10-15 Impact factor: 5.157

29 in total

1. Switching from simple to complex oscillations in calcium signaling.

Authors: U Kummer; L F Olsen; C J Dixon; A K Green; E Bornberg-Bauer; G Baier
Journal: Biophys J Date: 2000-09 Impact factor: 4.033

2. Gluconeogenesis stimulated by extracellular ATP is triggered by the initial increase in the intracellular Ca2+ concentration of the periphery of hepatocytes.

Authors: M Koike; T Kashiwagura; N Takeguchi
Journal: Biochem J Date: 1992-04-01 Impact factor: 3.857

Evidence for two Ca2(+)-mobilizing purinoceptors on rat hepatocytes.

Review 1. Spatial and temporal aspects of cell signalling.

2. Modulation of free Ca oscillations in single hepatocytes by changes in extracellular K+, Na+ and Ca2+.

3. P2-purinergic receptors are coupled to two signal transduction systems leading to inhibition of cAMP generation and to production of inositol trisphosphate in rat hepatocytes.

Review 4. Calcium oscillations in non-excitable cells.

5. Single cell measurements in research on calcium-mobilising purinoceptors.

6. Two distinct receptors for ATP can be distinguished in Swiss 3T6 mouse fibroblasts by their desensitization.

7. Extracellular ATP induces the release of calcium from intracellular stores without the activation of protein kinase C in Swiss 3T6 mouse fibroblasts.

8. Purification of (Ca2+-Mg2+)-ATPase from rat liver plasma membranes.

9. ATP-induced calcium mobilization in human neutrophils.

10. Characterization of cytosolic calcium oscillations induced by phenylephrine and vasopressin in single fura-2-loaded hepatocytes.

1. Switching from simple to complex oscillations in calcium signaling.

2. Gluconeogenesis stimulated by extracellular ATP is triggered by the initial increase in the intracellular Ca2+ concentration of the periphery of hepatocytes.

3. Transition from stochastic to deterministic behavior in calcium oscillations.

4. Evidence that 2-methylthioATP and 2-methylthioADP are both agonists at the rat hepatocyte P2Y(1) receptor.

5. Isolated rat hepatocytes can signal to other hepatocytes and bile duct cells by release of nucleotides.

6. Type III InsP3 receptor channel stays open in the presence of increased calcium.

7. Evidence that rat hepatocytes co-express functional P2Y1 and P2Y2 receptors.

8. The hepatitis B virus X protein elevates cytosolic calcium signals by modulating mitochondrial calcium uptake.

9. Actions of ADP, but not ATP, on cytosolic free Ca2+ in single rat hepatocytes mimicked by 2-methylthioATP.

10. Nonlinear time series analysis of nodulation factor induced calcium oscillations: evidence for deterministic chaos?