Literature DB >> 23864440

Enhancement of vindoline and vinblastine production in suspension-cultured cells of Catharanthus roseus by artemisinic acid elicitation.

Jinwei Liu1, Jianhua Zhu, Le Tang, Wei Wen, Shuangshuang Lv, Rongmin Yu.   

Abstract

Elicitation is an important strategy to improve production of secondary metabolites in vitro. Artemisinic acid was studied as a novel elicitor to enhance the yield of terpenoid indole alkaloids in the present paper. Our results demonstrated that the concentrations of vindoline and vinblastine were increased by sixfold and twofold, respectively, compared to those of the control group after treatment with artemisinic acid. To elucidate the underlying mechanism, we investigated the gene expression of four enzymes involved in the biosynthetic pathway of vinblastine in the suspension-cultured cells of Catharanthu sroseus. RT-PCR experiment showed that artemisinic acid was able to up-regulate the transcriptions of tryptophan decarboxylase, geraniol 10-hydroxylase, tabersonine 16-hydroxylase and deacetoxyvindoline 4-hydroxylase.

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Year:  2013        PMID： 23864440     DOI： 10.1007/s11274-013-1432-z

Source DB:  PubMed          Journal:  World J Microbiol Biotechnol        ISSN： 0959-3993            Impact factor:   3.312


  22 in total

1.  Molecular cloning and analysis of strictosidine beta-D-glucosidase, an enzyme in terpenoid indole alkaloid biosynthesis in Catharanthus roseus.

Authors:  A Geerlings; M M Ibañez; J Memelink; R van Der Heijden; R Verpoorte
Journal:  J Biol Chem       Date:  2000-02-04       Impact factor: 5.157

2.  Involvement of the octadecanoid pathway and protein phosphorylation in fungal elicitor-induced expression of terpenoid indole alkaloid biosynthetic genes in catharanthus roseus

Authors: 
Journal:  Plant Physiol       Date:  1999-04       Impact factor: 8.340

3.  Selection of fungal elicitors to increase indole alkaloid accumulation in catharanthus roseus suspension cell culture.

Authors:  J Zhao; W -H. Zhu; Q Hu
Journal:  Enzyme Microb Technol       Date:  2001-05-07       Impact factor: 3.493

4.  Transcription factor Agamous-like 12 from Arabidopsis promotes tissue-like organization and alkaloid biosynthesis in Catharanthus roseus suspension cells.

Authors:  Grégory Montiel; Christian Breton; Martine Thiersault; Vincent Burlat; Christian Jay-Allemand; Pascal Gantet
Journal:  Metab Eng       Date:  2006-10-21       Impact factor: 9.783

5.  Phytochrome is involved in the light-regulation of vindoline biosynthesis in catharanthus.

Authors:  R J Aerts; V De Luca
Journal:  Plant Physiol       Date:  1992-10       Impact factor: 8.340

6.  A Cytochrome P-450 Monooxygenase Catalyzes the First Step in the Conversion of Tabersonine to Vindoline in Catharanthus roseus.

Authors:  B. St-Pierre; V. De Luca
Journal:  Plant Physiol       Date:  1995-09       Impact factor: 8.340

7.  Vindoline biosynthesis is transcriptionally blocked in Catharanthus roseus cell suspension cultures.

Authors:  Felipe Vázquez-Flota; Vincenzo De Luca; Mildred Carrillo-Pech; Adriana Canto-Flick; Maria de Lourdes Miranda-Ham
Journal:  Mol Biotechnol       Date:  2002-09       Impact factor: 2.695

8.  A differential response to chemical elicitors in Catharanthus roseus in vitro cultures.

Authors:  Felipe Vázquez-Flota; Elizabeta Hernández-Domínguez; Ma de Lourdes Miranda-Ham; Miriam Monforte-González
Journal:  Biotechnol Lett       Date:  2008-11-22       Impact factor: 2.461

9.  The role of the octadecanoid pathway in the production of terpenoid indole alkaloids in Catharanthus roseus hairy roots under normal and UV-B stress conditions.

Authors:  Christie A M Peebles; Jacqueline V Shanks; Ka-Yiu San
Journal:  Biotechnol Bioeng       Date:  2009-08-15       Impact factor: 4.530

Review 10.  The value of plants used in traditional medicine for drug discovery.

Authors:  D S Fabricant; N R Farnsworth
Journal:  Environ Health Perspect       Date:  2001-03       Impact factor: 9.031
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  6 in total

Review 1.  Ornamental exterior versus therapeutic interior of Madagascar periwinkle (Catharanthus roseus): the two faces of a versatile herb.

Authors:  Naghmeh Nejat; Alireza Valdiani; David Cahill; Yee-How Tan; Mahmood Maziah; Rambod Abiri
Journal:  ScientificWorldJournal       Date:  2015-01-15

Review 2.  Biosynthesis and regulation of terpenoid indole alkaloids in Catharanthus roseus.

Authors:  Jianhua Zhu; Mingxuan Wang; Wei Wen; Rongmin Yu
Journal:  Pharmacogn Rev       Date:  2015 Jan-Jun

3.  Efficient production of vindoline from tabersonine by metabolically engineered Saccharomyces cerevisiae.

Authors:  Tengfei Liu; Ying Huang; Lihong Jiang; Chang Dong; Yuanwei Gou; Jiazhang Lian
Journal:  Commun Biol       Date:  2021-09-16

4.  Enzyme Inhibitors Cause Multiple Effects on Accumulation of Monoterpene Indole Alkaloids in Catharanthus Roseus Cambial Meristematic Cell Cultures.

Authors:  Zhou Pengfei; Zhu Jianhua; Yu Rongmin; Zi Jiachen
Journal:  Pharmacogn Mag       Date:  2017-11-13       Impact factor: 1.085

5.  Rhodium catalyzed diastereoselective synthesis of 2,2,3,3-tetrasubstituted indolines from N-sulfonyl-1,2,3-triazoles and ortho-vinylanilines.

Authors:  Dongari Yadagiri; Angula Chandra Shekar Reddy; Pazhamalai Anbarasan
Journal:  Chem Sci       Date:  2016-05-24       Impact factor: 9.825

6.  Enhancement of Vindoline and Catharanthine Accumulation, Antioxidant Enzymes Activities, and Gene Expression Levels in Catharanthus roseus Leaves by Chitooligosaccharides Elicitation.

Authors:  Wenzhu Tang; Xiaoqi Liu; Yuning He; Fan Yang
Journal:  Mar Drugs       Date:  2022-03-03       Impact factor: 5.118
  6 in total

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