Literature DB >> 23863943

Potential use of synthetic α-galactosyl-containing glycotopes of the parasite Trypanosoma cruzi as diagnostic antigens for Chagas disease.

Roger A Ashmus1, Nathaniel S Schocker, Yanira Cordero-Mendoza, Alexandre F Marques, Erika Y Monroy, Andrew Pardo, Luis Izquierdo, Montserrat Gállego, Joaquim Gascon, Igor C Almeida, Katja Michael.   

Abstract

A synthetic glycoarray containing non-reducing α-galactopyranosyl moieties related to mucin O-glycans of the parasite Trypanosoma cruzi was evaluated by a chemiluminescent enzyme-linked immunosorbent assay with sera from patients with chronic Chagas disease. Our data revealed the disaccharide Galα(1,3)Galβ as the immunodominant glycotope, which may eventually be employed as a diagnostic antigen for Chagas disease.

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Year:  2013        PMID： 23863943     DOI： 10.1039/c3ob40887f

Source DB:  PubMed          Journal:  Org Biomol Chem        ISSN： 1477-0520            Impact factor:   3.876


  12 in total

1.  Enhancing glycan isomer separations with metal ions and positive and negative polarity ion mobility spectrometry-mass spectrometry analyses.

Authors:  Xueyun Zheng; Xing Zhang; Nathaniel S Schocker; Ryan S Renslow; Daniel J Orton; Jamal Khamsi; Roger A Ashmus; Igor C Almeida; Keqi Tang; Catherine E Costello; Richard D Smith; Katja Michael; Erin S Baker
Journal:  Anal Bioanal Chem       Date:  2016-09-07       Impact factor: 4.142

2.  Reversed Immunoglycomics Identifies α-Galactosyl-Bearing Glycotopes Specific for Leishmania major Infection.

Authors:  Alba L Montoya; Victoria M Austin; Susana Portillo; Irodiel Vinales; Roger A Ashmus; Igor Estevao; Sohan R Jankuru; Yasser Alraey; Waleed S Al-Salem; Álvaro Acosta-Serrano; Igor C Almeida; Katja Michael
Journal:  JACS Au       Date:  2021-07-12

3.  Synthesis of Galα(1,3)Galβ(1,4)GlcNAcα-, Galβ(1,4)GlcNAcα- and GlcNAc-containing neoglycoproteins and their immunological evaluation in the context of Chagas disease.

Authors:  Nathaniel S Schocker; Susana Portillo; Carlos R N Brito; Alexandre F Marques; Igor C Almeida; Katja Michael
Journal:  Glycobiology       Date:  2015-09-18       Impact factor: 4.313

Review 4.  Biomarkers of therapeutic responses in chronic Chagas disease: state of the art and future perspectives.

Authors:  Maria-Jesus Pinazo; Maria-Carmen Thomas; Juan Bustamante; Igor Correia de Almeida; Manuel-Carlos Lopez; Joaquim Gascon
Journal:  Mem Inst Oswaldo Cruz       Date:  2015-04-28       Impact factor: 2.743

5.  Development of peptide-based lineage-specific serology for chronic Chagas disease: geographical and clinical distribution of epitope recognition.

Authors:  Tapan Bhattacharyya; Andrew K Falconar; Alejandro O Luquetti; Jaime A Costales; Mario J Grijalva; Michael D Lewis; Louisa A Messenger; Trang T Tran; Juan-David Ramirez; Felipe Guhl; Hernan J Carrasco; Patricio Diosque; Lineth Garcia; Sergey V Litvinov; Michael A Miles
Journal:  PLoS Negl Trop Dis       Date:  2014-05-22

6.  The Trypomastigote Small Surface Antigen (TSSA) regulates Trypanosoma cruzi infectivity and differentiation.

Authors:  María de Los Milagros Cámara; Gaspar E Cánepa; Andrés B Lantos; Virginia Balouz; Hai Yu; Xi Chen; Oscar Campetella; Juan Mucci; Carlos A Buscaglia
Journal:  PLoS Negl Trop Dis       Date:  2017-08-11

7.  An α-Gal-containing neoglycoprotein-based vaccine partially protects against murine cutaneous leishmaniasis caused by Leishmania major.

Authors:  Eva Iniguez; Nathaniel S Schocker; Krishanthi Subramaniam; Susana Portillo; Alba L Montoya; Waleed S Al-Salem; Caresse L Torres; Felipe Rodriguez; Otacilio C Moreira; Alvaro Acosta-Serrano; Katja Michael; Igor C Almeida; Rosa A Maldonado
Journal:  PLoS Negl Trop Dis       Date:  2017-10-25

8.  Target product profile for a test for the early assessment of treatment efficacy in Chagas disease patients: An expert consensus.

Authors:  Julio Alonso-Padilla; Marcelo Abril; Belkisyolé Alarcón de Noya; Igor C Almeida; Andrea Angheben; Tania Araujo Jorge; Eric Chatelain; Monica Esteva; Joaquim Gascón; Mario J Grijalva; Felipe Guhl; Alejandro Marcel Hasslocher-Moreno; Manuel Carlos López; Alejandro Luquetti; Oscar Noya; María Jesús Pinazo; Janine M Ramsey; Isabela Ribeiro; Andres Mariano Ruiz; Alejandro G Schijman; Sergio Sosa-Estani; M Carmen Thomas; Faustino Torrico; Maan Zrein; Albert Picado
Journal:  PLoS Negl Trop Dis       Date:  2020-04-23

Review 9.  The Glycan Structure of T. cruzi mucins Depends on the Host. Insights on the Chameleonic Galactose.

Authors:  María Eugenia Giorgi; Rosa M de Lederkremer
Journal:  Molecules       Date:  2020-08-27       Impact factor: 4.411

10.  Specific Recognition of β-Galactofuranose-Containing Glycans of Synthetic Neoglycoproteins by Sera of Chronic Chagas Disease Patients.

Authors:  Alba L Montoya; Eileni R Gil; Emily L Heydemann; Igor L Estevao; Bianca E Luna; Cameron C Ellis; Sohan R Jankuru; Belkisyolé Alarcón de Noya; Oscar Noya; Maria Paola Zago; Igor C Almeida; Katja Michael
Journal:  Molecules       Date:  2022-01-09       Impact factor: 4.927
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