Literature DB >> 23863169

ILK: a pseudokinase with a unique function in the integrin-actin linkage.

Sushmita Ghatak1, Jessica Morgner, Sara A Wickström.   

Abstract

ILK (integrin-linked kinase) is a central component of cell-matrix adhesions and an important regulator of integrin function. It forms a ternary complex with two other adaptor proteins, PINCH (particularly interesting cysteine- and histidine-rich protein) and parvin, forming the IPP (ILK-PINCH-parvin) complex that regulates the integrin-actin linkage as well as microtubule dynamics. These functions are essential for processes such as cell migration and matrix remodelling. The present review discusses the recent advances on the structural and functional characterization of ILK and the long-standing debate regarding its reported kinase activity.

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Year:  2013        PMID： 23863169     DOI： 10.1042/BST20130062

Source DB:  PubMed          Journal:  Biochem Soc Trans        ISSN： 0300-5127            Impact factor:   5.407


  32 in total

1.  Control of vascular permeability by adhesion molecules.

Authors:  Ingrid H Sarelius; Angela J Glading
Journal:  Tissue Barriers       Date:  2015-04-03

2.  Hippo signaling promotes lung epithelial lineage commitment by curbing Fgf10 and β-catenin signaling.

Authors:  Thomas Volckaert; Tingting Yuan; Jie Yuan; Eistine Boateng; Seantel Hopkins; Jin-San Zhang; Victor J Thannickal; Reinhard Fässler; Stijn P De Langhe
Journal:  Development       Date:  2019-01-16       Impact factor: 6.868

3.  The coordinate cellular response to insulin-like growth factor-I (IGF-I) and insulin-like growth factor-binding protein-2 (IGFBP-2) is regulated through vimentin binding to receptor tyrosine phosphatase β (RPTPβ).

Authors:  Xinchun Shen; Gang Xi; Christine Wai; David R Clemmons
Journal:  J Biol Chem       Date:  2015-03-18       Impact factor: 5.157

4.  Extracellular Matrix Signaling Through β3 Integrin Mediates Cocaine Cue-Induced Transient Synaptic Plasticity and Relapse.

Authors:  Constanza Garcia-Keller; Daniela Neuhofer; Ana-Clara Bobadilla; Sade Spencer; Vivian C Chioma; Cara Monforton; Peter W Kalivas
Journal:  Biol Psychiatry       Date:  2019-04-03       Impact factor: 13.382

5.  TGFB1 is secreted through an unconventional pathway dependent on the autophagic machinery and cytoskeletal regulators.

Authors:  Julian Nüchel; Sushmita Ghatak; Alexandra V Zuk; Anja Illerhaus; Matthias Mörgelin; Katrin Schönborn; Katrin Blumbach; Sara A Wickström; Thomas Krieg; Gerhard Sengle; Markus Plomann; Beate Eckes
Journal:  Autophagy       Date:  2018-03-11       Impact factor: 16.016

6.  Integrin α9 depletion promotes β-catenin degradation to suppress triple-negative breast cancer tumor growth and metastasis.

Authors:  Zhishan Wang; Yunfei Li; Yajuan Xiao; Hsuan-Pei Lin; Ping Yang; Brock Humphries; Tianyan Gao; Chengfeng Yang
Journal:  Int J Cancer       Date:  2019-05-03       Impact factor: 7.396

7.  Differences in binding to the ILK complex determines kindlin isoform adhesion localization and integrin activation.

Authors:  Clotilde Huet-Calderwood; Nina N Brahme; Nikit Kumar; Amy L Stiegler; Srikala Raghavan; Titus J Boggon; David A Calderwood
Journal:  J Cell Sci       Date:  2014-08-01       Impact factor: 5.285

Review 8.  Corticostriatal plasticity, neuronal ensembles, and regulation of drug-seeking behavior.

Authors:  Ana-Clara Bobadilla; Jasper A Heinsbroek; Cassandra D Gipson; William C Griffin; Christie D Fowler; Paul J Kenny; Peter W Kalivas
Journal:  Prog Brain Res       Date:  2017-10-12       Impact factor: 2.453

9.  Integrin-Linked Kinase Deficiency in Collecting Duct Principal Cell Promotes Necroptosis of Principal Cell and Contributes to Kidney Inflammation and Fibrosis.

Authors:  Ming Huang; Shuai Zhu; Huihui Huang; Jinzhao He; Kenji Tsuji; William W Jin; Dongping Xie; Onju Ham; Diane E Capen; Weining Lu; Teodor G Păunescu; Baoxue Yang; Hua A Jenny Lu
Journal:  J Am Soc Nephrol       Date:  2019-10-25       Impact factor: 10.121

10.  Role of integrin‑linked kinase in static compressive stress‑induced autophagy via phosphatidylinositol 3 kinase in human periodontal ligament cells.

Authors:  Rui Zou; Shiyang Wu; Yijie Wang; Xueping Kang; Shuyang Zhao; Haoyu Shi; Danqing Zheng; Bei Gao; Shuyu Ma; Lin Niu; Yunan Gao
Journal:  Int J Mol Med       Date:  2021-07-19       Impact factor: 4.101
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