Literature DB >> 23863139

The multifunctional RNase XRN2.

Takashi S Miki1, Helge Großhans.   

Abstract

Different classes of RNA function in various cellular processes, and their biogenesis and turnover involve diverse RNases for processing and degradation. XRN2 is a 5'→3' exoribonuclease that is evolutionarily conserved in eukaryotes. It is predominantly localized in the nucleus and recognizes single-stranded RNA with a 5'-terminal monophosphate to degrade it processively to mononucleotides. In the present paper, we review functions of XRN2 and its cofactors in maturation, surveillance and activity control of several classes of RNA such as pre-mRNA (precursor mRNA), rRNA and snoRNA (small nucleolar RNA).

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Year:  2013        PMID： 23863139     DOI： 10.1042/BST20130001

Source DB:  PubMed          Journal:  Biochem Soc Trans        ISSN： 0300-5127            Impact factor:   5.407


  25 in total

1.  Conserved factor Dhp1/Rat1/Xrn2 triggers premature transcription termination and nucleates heterochromatin to promote gene silencing.

Authors:  Venkata R Chalamcharla; H Diego Folco; Jothy Dhakshnamoorthy; Shiv I S Grewal
Journal:  Proc Natl Acad Sci U S A       Date:  2015-12-02       Impact factor: 11.205

2.  CPF Recruitment to Non-canonical Transcription Termination Sites Triggers Heterochromatin Assembly and Gene Silencing.

Authors:  Tommy V Vo; Jothy Dhakshnamoorthy; Madeline Larkin; Martin Zofall; Gobi Thillainadesan; Vanivilasini Balachandran; Sahana Holla; David Wheeler; Shiv I S Grewal
Journal:  Cell Rep       Date:  2019-07-02       Impact factor: 9.423

3.  XRN2 promotes EMT and metastasis through regulating maturation of miR-10a.

Authors:  H Zhang; Y Lu; E Chen; X Li; B Lv; H G Vikis; P Liu
Journal:  Oncogene       Date:  2017-03-20       Impact factor: 9.867

Review 4.  C/D-box snoRNAs form methylating and non-methylating ribonucleoprotein complexes: Old dogs show new tricks.

Authors:  Marina Falaleeva; Justin R Welden; Marilyn J Duncan; Stefan Stamm
Journal:  Bioessays       Date:  2017-05-15       Impact factor: 4.345

5.  Hepatitis C virus subverts liver-specific miR-122 to protect the viral genome from exoribonuclease Xrn2.

Authors:  Cecilia D Sedano; Peter Sarnow
Journal:  Cell Host Microbe       Date:  2014-08-13       Impact factor: 21.023

6.  Nuclear TARBP2 Drives Oncogenic Dysregulation of RNA Splicing and Decay.

Authors:  Lisa Fish; Albertas Navickas; Bruce Culbertson; Yichen Xu; Hoang C B Nguyen; Steven Zhang; Myles Hochman; Ross Okimoto; Brian D Dill; Henrik Molina; Hamed S Najafabadi; Claudio Alarcón; Davide Ruggero; Hani Goodarzi
Journal:  Mol Cell       Date:  2019-07-09       Impact factor: 17.970

7.  Dissecting the roles of the 5' exoribonucleases Xrn1 and Xrn2 in restricting hepatitis C virus replication.

Authors:  You Li; Daisuke Yamane; Stanley M Lemon
Journal:  J Virol       Date:  2015-02-11       Impact factor: 5.103

Review 8.  The yin and yang of hepatitis C: synthesis and decay of hepatitis C virus RNA.

Authors:  You Li; Daisuke Yamane; Takahiro Masaki; Stanley M Lemon
Journal:  Nat Rev Microbiol       Date:  2015-08-10       Impact factor: 60.633

9.  RNA-binding proteins regulate the expression of the immune activating ligand MICB.

Authors:  Sven Diederichs; Ofer Mandelboim; Daphna Nachmani; Tony Gutschner; Adi Reches
Journal:  Nat Commun       Date:  2014-06-13       Impact factor: 14.919

10.  Engineering of a conditional allele reveals multiple roles of XRN2 in Caenorhabditis elegans development and substrate specificity in microRNA turnover.

Authors:  Takashi S Miki; Stefan Rüegger; Dimos Gaidatzis; Michael B Stadler; Helge Großhans
Journal:  Nucleic Acids Res       Date:  2014-01-20       Impact factor: 16.971
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