Literature DB >> 23861277

Gelatinous bone marrow transformation secondary to unusual eating habits and drastic weight loss.

Rezwan Islam, Ruth Mahmood, Kajal V Sitwala.   

Abstract

Gelatinous bone marrow transformation (GMT), also known as starvation bone marrow, has been reported in a number of chronic illnesses, eating disorders (anorexia nervosa) and malignancies. We report the case of a 37-year-old man with a history of bipolar disorder and obesity (weighing >300 pounds) who presented due to recently developing a deep yellow colour to his skin. Over the past 2 years, through diet and exercise, he lost over 150 pounds. He reported running 6-8 miles per day and eating 'lots of squash'. We made the diagnosis of starvation hepatitis and bone marrow degeneration, and referred the patient to a dietician and haematologist/oncologist, where improvements were observed at 4 weeks follow-up.

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Year:  2013        PMID: 23861277      PMCID: PMC3736258          DOI: 10.1136/bcr-2013-200243

Source DB:  PubMed          Journal:  BMJ Case Rep        ISSN: 1757-790X


  22 in total

1.  Successful management of gelatinous transformation of the bone marrow in anorexia nervosa with hematopoietic growth factors.

Authors:  Roseleen S Charania; William F Kern; Shouvik Charkrabarty; Jennifer Holter
Journal:  Int J Eat Disord       Date:  2010-06-30       Impact factor: 4.861

2.  Histochemical studies of bone marrow cells in kwashiorkor.

Authors:  M Khalil; A S Kassem; M Hafez; S W Mehareb; R Girgis; M El Sawy
Journal:  J Trop Pediatr Environ Child Health       Date:  1977-04

3.  Gelatinous transformation of the bone marrow.

Authors:  J P Seaman; C R Kjeldsberg; A Linker
Journal:  Hum Pathol       Date:  1978-11       Impact factor: 3.466

4.  Gelatinous degeneration presenting as a preleukaemic syndrome.

Authors:  R Arranz; J J Gil-Fernandez; A Acevedo; J F Tomas; A Alegre; J M Fernandez-Rañada
Journal:  J Clin Pathol       Date:  1996-06       Impact factor: 3.411

5.  Bone marrow changes in anorexia nervosa are correlated with the amount of weight loss and not with other clinical findings.

Authors:  E Abella; E Feliu; I Granada; F Millá; A Oriol; J M Ribera; L Sánchez-Planell; L I Berga; J C Reverter; C Rozman
Journal:  Am J Clin Pathol       Date:  2002-10       Impact factor: 2.493

6.  Osteoblastic cells regulate the haematopoietic stem cell niche.

Authors:  L M Calvi; G B Adams; K W Weibrecht; J M Weber; D P Olson; M C Knight; R P Martin; E Schipani; P Divieti; F R Bringhurst; L A Milner; H M Kronenberg; D T Scadden
Journal:  Nature       Date:  2003-10-23       Impact factor: 49.962

7.  Increased bone marrow fat in anorexia nervosa.

Authors:  Miriam A Bredella; Pouneh K Fazeli; Karen K Miller; Madhusmita Misra; Martin Torriani; Bijoy J Thomas; Reza Hosseini Ghomi; Clifford J Rosen; Anne Klibanski
Journal:  J Clin Endocrinol Metab       Date:  2009-03-24       Impact factor: 5.958

Review 8.  Leptin in the regulation of immunity, inflammation, and hematopoiesis.

Authors:  G Fantuzzi; R Faggioni
Journal:  J Leukoc Biol       Date:  2000-10       Impact factor: 4.962

9.  Bone-marrow adipocytes as negative regulators of the haematopoietic microenvironment.

Authors:  Olaia Naveiras; Valentina Nardi; Pamela L Wenzel; Peter V Hauschka; Frederic Fahey; George Q Daley
Journal:  Nature       Date:  2009-06-10       Impact factor: 49.962

10.  Long-term survival of a patient with bone marrow gelatinous degeneration of idiopathic origin.

Authors:  Pasquale Niscola; Massimiliano Palombi; Stefano Fratoni; Malgorzata Monika Trawinska; Laura Scaramucci; Andrea Tendas; Marco Giovannini; Alessio Perrotti; Paolo de Fabritiis
Journal:  Korean J Hematol       Date:  2012-12-24
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  3 in total

Review 1.  Medical complications of anorexia nervosa and their treatments: an update on some critical aspects.

Authors:  Carrie Brown; Philip S Mehler
Journal:  Eat Weight Disord       Date:  2015-07-03       Impact factor: 4.652

Review 2.  Gelatinous transformation of bone marrow: rare or underdiagnosed?

Authors:  Khushdeep Kaur Shergill; Gagandeep Singh Shergill; Hari Janardanan Pillai
Journal:  Autops Case Rep       Date:  2017-12-08

3.  Gelatinous bone marrow transformation due to extensive weight loss in median arcuate ligament syndrome.

Authors:  Lorena Miguelañez Matute; Desiree van Noord; Nazik Rayman; Samara S Guillen
Journal:  BMJ Case Rep       Date:  2022-01-17
  3 in total

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