Literature DB >> 23861274

Fountain of steroid from an ectopic ACTH-producing tumour.

Tom Edward Ngo Lo1, Cecilia Alegado Jimeno.   

Abstract

This case is of a 39-year-old Filipino woman who within 2 months developed, Cushing's features she had no known comorbidities and no history of steroid intake. The patient also presented with hyperpigmentation of knuckles and toes, metabolic alkalosis and persistent hypokalaemia noted as proximal muscle weakness. The patient was referred to our institution for acutely worsening behavioural and psychiatric changes. Work-up for endogenous Cushing's syndrome revealed a significant adrenocorticotropic hormone production from an ectopic source. Further imaging was requested to locate the tumour, but the patient eventually succumbed to the drastic complications of hypercortisolism. On autopsy, the patient was found to have an ectopic well-differentiated neuroendocrine tumour located at the pancreatic head with metastasis to the right hepatic lobe.

Entities:  

Mesh:

Year:  2013        PMID: 23861274      PMCID: PMC3736644          DOI: 10.1136/bcr-2013-010368

Source DB:  PubMed          Journal:  BMJ Case Rep        ISSN: 1757-790X


  6 in total

1.  Studies on ectopic ACTH-producing tumors. II. Clinical and biochemical features of 30 cases.

Authors:  H Imura; S Matsukura; H Yamamoto; Y Hirata; Y Nakai
Journal:  Cancer       Date:  1975-05       Impact factor: 6.860

2.  The ectopic ACTH syndrome.

Authors:  G W Liddle; J R Givens; W E Nicholson; D P Island
Journal:  Cancer Res       Date:  1965-08       Impact factor: 12.701

3.  Changing epidemiology of small-cell lung cancer in the United States over the last 30 years: analysis of the surveillance, epidemiologic, and end results database.

Authors:  Ramaswamy Govindan; Nathan Page; Daniel Morgensztern; William Read; Ryan Tierney; Anna Vlahiotis; Edward L Spitznagel; Jay Piccirillo
Journal:  J Clin Oncol       Date:  2006-10-01       Impact factor: 44.544

4.  Cushing's syndrome due to ectopic corticotropin secretion: twenty years' experience at the National Institutes of Health.

Authors:  Ioannis Ilias; David J Torpy; Karel Pacak; Nancy Mullen; Robert A Wesley; Lynnette K Nieman
Journal:  J Clin Endocrinol Metab       Date:  2005-05-24       Impact factor: 5.958

5.  Ectopic adrenocorticotropic hormone syndrome: localization studies in 28 patients.

Authors:  J L Doppman; L Nieman; D L Miller; H I Pass; R Chang; G B Cutler; M Schaaf; G P Chrousos; J A Norton; H A Ziessman
Journal:  Radiology       Date:  1989-07       Impact factor: 11.105

6.  11 beta-Hydroxysteroid dehydrogenase activity in Cushing's syndrome: explaining the mineralocorticoid excess state of the ectopic adrenocorticotropin syndrome.

Authors:  P M Stewart; B R Walker; G Holder; D O'Halloran; C H Shackleton
Journal:  J Clin Endocrinol Metab       Date:  1995-12       Impact factor: 5.958

  6 in total
  1 in total

1.  ACTH-Producing Pancreatic Neuroendocrine Tumor Presenting with Severe Hypokalemic Alkalosis: A Case Report.

Authors:  Shirin Attarian; Steven K Libutti; Jennifer Chuy
Journal:  J Gastrointest Cancer       Date:  2016-06
  1 in total

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