| Literature DB >> 23861228 |
M Reza Nejadnik1, Xia Yang, Tokio Mimura, Zeinab Tahmasebi Birgani, Pamela Habibovic, Kiyoshi Itatani, John A Jansen, Jons Hilborn, Dmitri Ossipov, Antonios G Mikos, Sander C G Leeuwenburgh.
Abstract
This study demonstrates, for the first time, that synthetic PEG-based hydrogels can be cross-linked reversibly by calcium upon functionalization of the polymer backbone with bisphosphonate groups (BPs) that allow for the formation of strong coordination bonds with divalent metal ions such as Mg(2+) and Ca(2+). More specifically, it is shown that BP-functionalized hydrogels can be shaped by providing calcium ions as reversible physical cross-linkers.Entities:
Keywords: bisphosphonates; calcium-binding; coordination bonds; hydrogels; metal-polymer complexes
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Year: 2013 PMID： 23861228 DOI： 10.1002/mabi.201300117
Source DB: PubMed Journal: Macromol Biosci ISSN： 1616-5187 Impact factor: 4.979