Literature DB >> 23860596

A nanocarrier based on a genetically engineered protein cage to deliver doxorubicin to human hepatocellular carcinoma cells.

Riki Toita1, Masaharu Murata, Kana Abe, Sayoko Narahara, Jing Shu Piao, Jeong-Hun Kang, Makoto Hashizume.   

Abstract

Herein, we report the preparation of genetically engineered protein cages (HspG41C-SP94), taken up selectively by human hepatocellular carcinoma (HCC) cells. An engineered protein cage-doxorubicin (DOX) conjugate was as cytotoxic as free DOX against HCC cells but much less cytotoxic against normal hepatocytes.

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Year:  2013        PMID： 23860596     DOI： 10.1039/c3cc44508a

Source DB:  PubMed          Journal:  Chem Commun (Camb)        ISSN： 1359-7345            Impact factor:   6.222


  9 in total

Review 1.  Nanocaged platforms: modification, drug delivery and nanotoxicity. Opening synthetic cages to release the tiger.

Authors:  Mahdi Karimi; Parham Sahandi Zangabad; Fatemeh Mehdizadeh; Hedieh Malekzad; Alireza Ghasemi; Sajad Bahrami; Hossein Zare; Mohsen Moghoofei; Amin Hekmatmanesh; Michael R Hamblin
Journal:  Nanoscale       Date:  2017-01-26       Impact factor: 7.790

Review 2.  Applications of human hepatitis B virus preS domain in bio- and nanotechnology.

Authors:  Riki Toita; Takahito Kawano; Jeong-Hun Kang; Masaharu Murata
Journal:  World J Gastroenterol       Date:  2015-06-28       Impact factor: 5.742

Review 3.  Active radar guides missile to its target: receptor-based targeted treatment of hepatocellular carcinoma by nanoparticulate systems.

Authors:  Jing-Jun Yan; Jia-Zhi Liao; Ju-Sheng Lin; Xing-Xing He
Journal:  Tumour Biol       Date:  2014-11-26

Review 4.  Bacterial Nanocompartments: Structures, Functions, and Applications.

Authors:  Harry Benjamin McDowell; Egbert Hoiczyk
Journal:  J Bacteriol       Date:  2021-10-04       Impact factor: 3.476

5.  Systemic delivery of protein nanocages bearing CTT peptides for enhanced imaging of MMP-2 expression in metastatic tumor models.

Authors:  Takahito Kawano; Masaharu Murata; Jing Shu Piao; Sayoko Narahara; Nobuhito Hamano; Jeong-Hun Kang; Makoto Hashizume
Journal:  Int J Mol Sci       Date:  2014-12-24       Impact factor: 5.923

6.  Investigation of SP94 Peptide as a Specific Probe for Hepatocellular Carcinoma Imaging and Therapy.

Authors:  Yanli Li; Yan Hu; Jie Xiao; Guobing Liu; Xiao Li; Yanzhao Zhao; Hui Tan; Hongcheng Shi; Dengfeng Cheng
Journal:  Sci Rep       Date:  2016-09-21       Impact factor: 4.379

7.  Encapsulating Active Pharmaceutical Ingredients in Self-Assembling Adamantanes with Short DNA Zippers.

Authors:  Helmut Griesser; Alexander Schwenger; Clemens Richert
Journal:  ChemMedChem       Date:  2017-10-09       Impact factor: 3.466

Review 8.  Encapsulins-Bacterial Protein Nanocompartments: Structure, Properties, and Application.

Authors:  Anna N Gabashvili; Nelly S Chmelyuk; Maria V Efremova; Julia A Malinovskaya; Alevtina S Semkina; Maxim A Abakumov
Journal:  Biomolecules       Date:  2020-06-26

9.  Genetically Engineered Hepatitis C Virus-like Particles (HCV-LPs) Tagged with SP94 Peptide to Acquire Selectivity to Liver Cancer Cells via Grp78.

Authors:  Dina Mofed; Mohamed A Wahba; Tamer Z Salem
Journal:  Curr Issues Mol Biol       Date:  2022-08-20       Impact factor: 2.976
  9 in total

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