BACKGROUND/AIMS: Treatment of children with growth disorders with recombinant human growth hormone is necessary for improved outcomes, including final height. METHODS: Adherence data from the Observational Study Saizen®-online, recorded with the easypod™ device collected between October 2009 and May 2011, were analyzed in pediatric patients receiving recombinant human growth hormone treatment for a variety of growth disorders. RESULTS: Data from 75 children (46 boys, 29 girls) with different growth disorders were analyzed over a period of 343 ± 201 (SD) days. Boys and girls showed similar mean ± SD adherence rates of 90.5 ± 3.1% and 92.2 ± 10.7%, respectively. Pubertal children (n = 41) had a significantly lower adherence rate (89.1 ± 13.7%) than prepubertal children (n = 29) (96.5 ± 3.9%; p < 0.005). There were nonsignificant differences in adherence rates according to diagnosis: growth hormone deficiency (n = 48) 91.4 ± 11.0%, small for gestational age (n = 18) 91.1 ± 15.3%, Turner syndrome (n = 6) 86.0 ± 14.5%, and chronic renal failure (n = 3) 99.3 ± 1.0%, although the latter two groups were small. CONCLUSION: Our data indicate that only a small number of pediatric patients using the easypod device had poor adherence to treatment. Further reliable adherence data are required to identify factors affecting long-term adherence in this population.
BACKGROUND/AIMS: Treatment of children with growth disorders with recombinant humangrowth hormone is necessary for improved outcomes, including final height. METHODS: Adherence data from the Observational Study Saizen®-online, recorded with the easypod™ device collected between October 2009 and May 2011, were analyzed in pediatric patients receiving recombinant humangrowth hormone treatment for a variety of growth disorders. RESULTS: Data from 75 children (46 boys, 29 girls) with different growth disorders were analyzed over a period of 343 ± 201 (SD) days. Boys and girls showed similar mean ± SD adherence rates of 90.5 ± 3.1% and 92.2 ± 10.7%, respectively. Pubertal children (n = 41) had a significantly lower adherence rate (89.1 ± 13.7%) than prepubertal children (n = 29) (96.5 ± 3.9%; p < 0.005). There were nonsignificant differences in adherence rates according to diagnosis: growth hormone deficiency (n = 48) 91.4 ± 11.0%, small for gestational age (n = 18) 91.1 ± 15.3%, Turner syndrome (n = 6) 86.0 ± 14.5%, and chronic renal failure (n = 3) 99.3 ± 1.0%, although the latter two groups were small. CONCLUSION: Our data indicate that only a small number of pediatric patients using the easypod device had poor adherence to treatment. Further reliable adherence data are required to identify factors affecting long-term adherence in this population.
Authors: Nancy M Rodig; Kelly C McDermott; Michael F Schneider; Hilary M Hotchkiss; Ora Yadin; Mouin G Seikaly; Susan L Furth; Bradley A Warady Journal: Pediatr Nephrol Date: 2014-04-12 Impact factor: 3.714
Authors: Meliha Demiral; Edip Unal; Birsen Baysal; Rıza Taner Baran; Hüseyin Demirbilek; Mehmet Nuri Özbek Journal: J Clin Res Pediatr Endocrinol Date: 2020-03-11
Authors: A Blanco-López; C Antillón-Ferreira; E Saavedra-Castillo; M Barrientos-Pérez; H Rivero-Escalante; O Flores-Caloca; R Calzada-León; C C Rosas-Guerra; E Koledova; E Chiquete; A Ayala-Estrada Journal: J Endocrinol Invest Date: 2020-04-01 Impact factor: 4.256