Literature DB >> 23860362

Warkmycin, a novel angucycline antibiotic produced by Streptomyces sp. Acta 2930*.

Soleiman E Helaly1, Michael Goodfellow, Heidi Zinecker, Johannes F Imhoff, Roderich D Süssmuth, Hans-Peter Fiedler.   

Abstract

A novel angucycline-type antibiotic, warkmycin, was isolated from the culture filtrate of Streptomyces strain Acta 2930. Its chemical structure was elucidated by HR-MS, one-dimensional and 2D NMR experiments. The compound inhibits the growth of Gram-positive bacteria and shows a strong antiproliferative activity against mouse fibroblast cell line NIH-3T3 and human cancer cell lines HepG2 and HT29.

Entities:  

Mesh：

Substances：

Year:  2013        PMID： 23860362     DOI： 10.1038/ja.2013.74

Source DB:  PubMed          Journal:  J Antibiot (Tokyo)        ISSN： 0021-8820            Impact factor:   2.649


  3 in total

1.  Searching for Glycosylated Natural Products in Actinomycetes and Identification of Novel Macrolactams and Angucyclines.

Authors:  Mónica G Malmierca; Lorena González-Montes; Ignacio Pérez-Victoria; Carlos Sialer; Alfredo F Braña; Raúl García Salcedo; Jesús Martín; Fernando Reyes; Carmen Méndez; Carlos Olano; José A Salas
Journal:  Front Microbiol       Date:  2018-01-30       Impact factor: 5.640

2.  Stress-Driven Discovery of New Angucycline-Type Antibiotics from a Marine Streptomyces pratensis NA-ZhouS1.

Authors:  Najeeb Akhter; Yaqin Liu; Bibi Nazia Auckloo; Yutong Shi; Kuiwu Wang; Juanjuan Chen; Xiaodan Wu; Bin Wu
Journal:  Mar Drugs       Date:  2018-09-12       Impact factor: 5.118

3.  Exploration of Diverse Secondary Metabolites From Streptomyces sp. YINM00001, Using Genome Mining and One Strain Many Compounds Approach.

Authors:  Tao Liu; Zhen Ren; Wei-Xun Chunyu; Gui-Ding Li; Xiu Chen; Zhou-Tian-Le Zhang; Hui-Bing Sun; Mei Wang; Tian-Peng Xie; Meng Wang; Jing-Yuan Chen; Hao Zhou; Zhong-Tao Ding; Min Yin
Journal:  Front Microbiol       Date:  2022-02-10       Impact factor: 5.640
  3 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.