INTRODUCTION: The present study aims to detect the specific and common impairment index relative to evoked brain potentials (EBPS ) in deficit schizophrenia (DS) and nondeficit schizophrenia (NDS), and investigates the relationship between EBPs and clinical variables. METHODS: The study used EBPs in 21 patients with DS, 38 patients with NDS, and 50 healthy controls (HCs) to investigate P300 waves, mismatch negative (MMN), sensory gating (SG) P50 and contingent negative variation (CNV). A comparison of three groups and the relationship between EBPs and clinical variables were performed using general linear model analyses and partial correlation, respectively. RESULTS: Compared with HCs, both groups of patients showed delayed N1 , N2 , and P3a latency, and reduced N1 and N2 amplitude. The MMN showed delayed latency. The P50 ratios and the inhibited ratios were impaired, whereas SG loss ratios increased. CNV amplitude was reduced. Compared with HCs, NDS showed delayed latency of S2'-C in CNV, whereas DS showed shortened latency. Only NDS, when compared with HCs, showed delayed latency of P3b , Also, only DS, when compared with HCs, showed delayed latency of point A in CNV. Latency of point A in CNV of DS, correlated with a poorer Global Assessment of Functioning Scale (6 weeks) and was independent of clinical characteristics. DISCUSSION: Schizophrenia represents a clinical syndrome with shared impairments in brain function, whereas DS is a relatively homogeneous subgroup of schizophrenia with unique pathophysiological changes.
INTRODUCTION: The present study aims to detect the specific and common impairment index relative to evoked brain potentials (EBPS ) in deficit schizophrenia (DS) and nondeficit schizophrenia (NDS), and investigates the relationship between EBPs and clinical variables. METHODS: The study used EBPs in 21 patients with DS, 38 patients with NDS, and 50 healthy controls (HCs) to investigate P300 waves, mismatch negative (MMN), sensory gating (SG) P50 and contingent negative variation (CNV). A comparison of three groups and the relationship between EBPs and clinical variables were performed using general linear model analyses and partial correlation, respectively. RESULTS: Compared with HCs, both groups of patients showed delayed N1 , N2 , and P3a latency, and reduced N1 and N2 amplitude. The MMN showed delayed latency. The P50 ratios and the inhibited ratios were impaired, whereas SG loss ratios increased. CNV amplitude was reduced. Compared with HCs, NDS showed delayed latency of S2'-C in CNV, whereas DS showed shortened latency. Only NDS, when compared with HCs, showed delayed latency of P3b , Also, only DS, when compared with HCs, showed delayed latency of point A in CNV. Latency of point A in CNV of DS, correlated with a poorer Global Assessment of Functioning Scale (6 weeks) and was independent of clinical characteristics. DISCUSSION: Schizophrenia represents a clinical syndrome with shared impairments in brain function, whereas DS is a relatively homogeneous subgroup of schizophrenia with unique pathophysiological changes.
Authors: Michael Avissar; Shanghong Xie; Blair Vail; Javier Lopez-Calderon; Yuanjia Wang; Daniel C Javitt Journal: Schizophr Res Date: 2017-07-11 Impact factor: 4.939
Authors: Giulia M Giordano; Francesco Brando; Andrea Perrottelli; Giorgio Di Lorenzo; Alberto Siracusano; Luigi Giuliani; Pasquale Pezzella; Mario Altamura; Antonello Bellomo; Giammarco Cascino; Antonio Del Casale; Palmiero Monteleone; Maurizio Pompili; Silvana Galderisi; Mario Maj Journal: Front Psychiatry Date: 2021-12-20 Impact factor: 4.157
Authors: Christian Kärgel; Gudrun Sartory; Daniela Kariofillis; Jens Wiltfang; Bernhard W Müller Journal: PLoS One Date: 2014-04-16 Impact factor: 3.240