PURPOSE: High-resolution visualization of cartilage canals has been restricted to histological methods and contrast-enhanced imaging. In this study, the feasibility of non-contrast-enhanced susceptibility weighted imaging (SWI) for visualization of the cartilage canals was investigated ex vivo at 9.4 T, further explored at 7 and 3 T and demonstrated in vivo at 7 T, using a porcine animal model. METHODS: SWI scans of specimens of distal femur and humerus from 1 to 8 week-old piglets were conducted at 9.4 T using 3D-GRE sequence and SWI post-processing. The stifle joints of a 2-week old piglet were scanned ex vivo at 7 and 3 T. Finally, the same sites of a 3-week-old piglet were scanned, in vivo, at 7 T under general anesthesia using the vendor-provided sequences. RESULTS: High-contrast visualization of the cartilage canals was obtained ex vivo, especially at higher field strengths; the results were confirmed histologically. In vivo feasibility was demonstrated at 7 T and comparison of ex vivo scans at 3 and 7 T indicated feasibility of using SWI at 3 T. CONCLUSIONS: High-resolution 3D visualization of cartilage canals was demonstrated using SWI. This demonstration of fully noninvasive visualization opens new avenues to explore skeletal maturation and the role of vascular supply for diseases such as osteochondrosis.
PURPOSE: High-resolution visualization of cartilage canals has been restricted to histological methods and contrast-enhanced imaging. In this study, the feasibility of non-contrast-enhanced susceptibility weighted imaging (SWI) for visualization of the cartilage canals was investigated ex vivo at 9.4 T, further explored at 7 and 3 T and demonstrated in vivo at 7 T, using a porcine animal model. METHODS: SWI scans of specimens of distal femur and humerus from 1 to 8 week-old piglets were conducted at 9.4 T using 3D-GRE sequence and SWI post-processing. The stifle joints of a 2-week old piglet were scanned ex vivo at 7 and 3 T. Finally, the same sites of a 3-week-old piglet were scanned, in vivo, at 7 T under general anesthesia using the vendor-provided sequences. RESULTS: High-contrast visualization of the cartilage canals was obtained ex vivo, especially at higher field strengths; the results were confirmed histologically. In vivo feasibility was demonstrated at 7 T and comparison of ex vivo scans at 3 and 7 T indicated feasibility of using SWI at 3 T. CONCLUSIONS: High-resolution 3D visualization of cartilage canals was demonstrated using SWI. This demonstration of fully noninvasive visualization opens new avenues to explore skeletal maturation and the role of vascular supply for diseases such as osteochondrosis.
Authors: Pierre-François Van de Moortele; Can Akgun; Gregor Adriany; Steen Moeller; Johannes Ritter; Christopher M Collins; Michael B Smith; J Thomas Vaughan; Kāmil Uğurbil Journal: Magn Reson Med Date: 2005-12 Impact factor: 4.668
Authors: P S Babyn; H K Kim; C Lemaire; H K Gahunia; A Cross; J DeNanassy; K P Pritzker Journal: J Magn Reson Imaging Date: 1996 Jan-Feb Impact factor: 4.813
Authors: D Jaramillo; O L Villegas-Medina; D K Doty; J R Dwek; B J Ransil; R V Mulkern; F Shapiro Journal: AJR Am J Roentgenol Date: 1996-04 Impact factor: 3.959
Authors: Ferenc Tóth; Marc A Tompkins; Kevin G Shea; Jutta M Ellermann; Cathy S Carlson Journal: J Bone Joint Surg Am Date: 2018-12-19 Impact factor: 5.284
Authors: Casey P Johnson; Luning Wang; Ferenc Tóth; Olumide Aruwajoye; Brooke Kirkham; Cathy S Carlson; Harry K W Kim; Jutta M Ellermann Journal: J Magn Reson Imaging Date: 2018-12-17 Impact factor: 4.813
Authors: Luning Wang; Mikko J Nissi; Ferenc Toth; Casey P Johnson; Michael Garwood; Cathy S Carlson; Jutta Ellermann Journal: Magn Reson Med Date: 2016-03-28 Impact factor: 4.668
Authors: Ferenc Tóth; Mikko J Nissi; Jutta M Ellermann; Luning Wang; Kevin G Shea; John Polousky; Cathy S Carlson Journal: Am J Sports Med Date: 2015-08-18 Impact factor: 6.202
Authors: Ferenc Tóth; Frédéric H David; Elizabeth LaFond; Luning Wang; Jutta M Ellermann; Cathy S Carlson Journal: J Orthop Res Date: 2016-06-19 Impact factor: 3.494
Authors: Zhirui Jiang; Casey P Johnson; Olli Nykänen; Mikko Nissi; Yian Khai Lau; Meilun Wu; Margret L Casal; Lachlan J Smith Journal: Connect Tissue Res Date: 2021-01-11 Impact factor: 3.417
Authors: Alexander Kolb; Simon Robinson; David Stelzeneder; Markus Schreiner; Catharina Chiari; Reinhard Windhager; Siegfried Trattnig; Klaus Bohndorf Journal: Eur Radiol Date: 2018-02-26 Impact factor: 5.315
Authors: Jutta M Ellermann; Kai D Ludwig; Mikko J Nissi; Casey P Johnson; John P Strupp; Luning Wang; Štefan Zbýň; Ferenc Tóth; Elizabeth Arendt; Marc Tompkins; Kevin Shea; Cathy S Carlson Journal: JB JS Open Access Date: 2019-12-05