Literature DB >> 23857298

Albendazole and its derivative JVG9 induce encystation on Giardia intestinalis trophozoites.

Armando Pérez-Rangel1, José Manuel Hernández, Araceli Castillo-Romero, Lilián Yépez-Mulia, Rafael Castillo, Francisco Hernández-Luis, Benjamín Nogueda-Torres, Juan Pedro Luna-Arias, Gerardo Radilla, Gloria León-Avila.   

Abstract

In the present study, we evaluated the effect of an albendazole (ABZ) derivative JVG9 on cultured Giardia intestinalis. To assess the JVG9 effects, we evaluated the tubulin cytoskeleton by confocal microscopy, and we found that the characteristic staining was modified. The scanning electron microscopy images revealed extremely damaged trophozoites and cyst-like cells. The confocal images revealed that this drug triggered the expression of cyst wall protein 1 and encystation. We also found that at low doses, AL triggered the encystation process too.

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Year:  2013        PMID： 23857298     DOI： 10.1007/s00436-013-3521-1

Source DB:  PubMed          Journal:  Parasitol Res        ISSN： 0932-0113            Impact factor:   2.289


  25 in total

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Authors:  Moema A Hausen; Richard Pereira de Oliveira; Ana Paula Rocha Gadelha; Loraine Campanati; Jorge José de Carvalho; Laís de Carvalho; Helene Santos Barbosa
Journal:  Parasitol Res       Date:  2009-05-12       Impact factor: 2.289

8.  Effects of albendazole on Entamoeba histolytica and Giardia lamblia trophozoites.

Authors:  B Chávez; M Espinosa-Cantellano; R Cedillo Rivera; A Ramírez; A Martínez-Palomo
Journal:  Arch Med Res       Date:  1992       Impact factor: 2.235

9.  In vitro resistance to 5-nitroimidazoles and benzimidazoles in Giardia duodenalis: variability and variation in gene expression.

Authors:  Raúl Argüello-García; Maricela Cruz-Soto; Lydia Romero-Montoya; Guadalupe Ortega-Pierres
Journal:  Infect Genet Evol       Date:  2009-05-27       Impact factor: 3.342

10.  Albendazole sensitizes cancer cells to ionizing radiation.

Authors:  Kirtesh Patel; Nicole A Doudican; Peter B Schiff; Seth J Orlow
Journal:  Radiat Oncol       Date:  2011-11-17       Impact factor: 3.481
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  2 in total

1.  Tigecycline inhibits proliferation of Acanthamoeba castellanii.

Authors:  Bijay Kumar Jha; Incheol Seo; Hyun-Hee Kong; Seong-Il Suh; Min-Ho Suh; Won-Ki Baek
Journal:  Parasitol Res       Date:  2015-01-07       Impact factor: 2.289

2.  Characterisation of the in vitro activity of a Nitazoxanide-N-methyl-1H-benzimidazole hybrid molecule against albendazole and nitazoxanide susceptible and resistant strains of Giardia intestinalis and its in vivo giardicidal activity.

Authors:  Félix Matadamas-Martínez; Benjamín Nogueda-Torres; Rafael Castillo; Alicia Hernández-Campos; María de la Luz Barrera-Valdes; Gloria León-Ávila; José Manuel Hernández; Lilián Yépez-Mulia
Journal:  Mem Inst Oswaldo Cruz       Date:  2020-02-07       Impact factor: 2.743
  2 in total

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