| Literature DB >> 23856939 |
Takashi Kuribayashi1, Tetsuro Seita, Katsuhito Kawato, Shunsuke Yamazaki, Shizuo Yamamoto.
Abstract
Synthesis of α2-macoglobulin (α2M) by 3-week-old juvenile rats was compared to that of mature 7- and 11-week-old rats. Serum concentrations of α2M, interleukin (IL)-6- and cytokine-induced neutrophil chemoattractant (CINC)-1 were measured by enzyme-linked immunosorbent assay. The area under the concentration vs. time curve (AUC) for α2M was significantly different among the three groups. The synthesis of α2M increased in an age-dependent manner. No significant difference was observed for the AUC of IL-6, but that of CINC-1 in 3-week-old rats was significantly lower than that in 7- or 11-week-old rats. These results suggest that synthesis of α2M was increased in mature compared to juvenile rats, possibly due to differences in liver function. The maximum concentration of CINC-1 in 3-week-old rats was observed 6 h after turpentine oil injection. The serum concentrations of IL-6 and CINC-1 increased more quickly in juvenile rats than in mature rats after inflammatory stimulation.Entities:
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Year: 2013 PMID： 23856939 DOI： 10.1007/s10753-013-9685-0
Source DB: PubMed Journal: Inflammation ISSN： 0360-3997 Impact factor: 4.092