Literature DB >> 23856645

Sirtuins as therapeutic targets of ALS.

Giulio Maria Pasinetti1, Amanda E Bilski, Wei Zhao.   

Abstract

Sirtuins have received a lot of attention in biological functions associated with metabolism, survival development, and most recently, neurodegeneration. The versatile role of sirtuins can be readily redirected for drug discovery studies for novel treatment in amyotrophic lateral sclerosis (ALS), as presented in this highlight, by sirtuin-mediated ketogenic responses influencing mitochondrial function.

Entities:  

Mesh：

Substances：

Year:  2013        PMID： 23856645      PMCID： PMC3760621          DOI： 10.1038/cr.2013.94

Source DB:  PubMed          Journal:  Cell Res        ISSN： 1001-0602            Impact factor:   25.617


  10 in total

1.  Regulation of Caenorhabditis elegans lifespan by sir-2.1 transgenes.

Authors:  Mohan Viswanathan; Leonard Guarente
Journal:  Nature       Date:  2011-09-21       Impact factor: 49.962

2.  Neuronal SIRT1 activation as a novel mechanism underlying the prevention of Alzheimer disease amyloid neuropathology by calorie restriction.

Authors:  Weiping Qin; Tianle Yang; Lap Ho; Zhong Zhao; Jun Wang; Linghong Chen; Wei Zhao; Meenakshisundaram Thiyagarajan; Donal MacGrogan; Joseph T Rodgers; Pere Puigserver; Junichi Sadoshima; Haiteng Deng; Steven Pedrini; Samuel Gandy; Anthony A Sauve; Giulio M Pasinetti
Journal:  J Biol Chem       Date:  2006-06-02       Impact factor: 5.157

3.  Differential sirtuin expression patterns in amyotrophic lateral sclerosis (ALS) postmortem tissue: neuroprotective or neurotoxic properties of sirtuins in ALS?

Authors:  Sonja Körner; Sebastian Böselt; Nadine Thau; Klaus Jan Rath; Reinhard Dengler; Susanne Petri
Journal:  Neurodegener Dis       Date:  2012-07-10       Impact factor: 2.977

4.  Mutant SOD1G93A triggers mitochondrial fragmentation in spinal cord motor neurons: neuroprotection by SIRT3 and PGC-1α.

Authors:  Wenjun Song; Yuting Song; Brad Kincaid; Blaise Bossy; Ella Bossy-Wetzel
Journal:  Neurobiol Dis       Date:  2012-07-20       Impact factor: 5.996

5.  Peroxisome proliferator-activated receptor-gamma coactivator-1alpha controls transcription of the Sirt3 gene, an essential component of the thermogenic brown adipocyte phenotype.

Authors:  Albert Giralt; Elayne Hondares; Josep A Villena; Francesc Ribas; Julieta Díaz-Delfín; Marta Giralt; Roser Iglesias; Francesc Villarroya
Journal:  J Biol Chem       Date:  2011-03-27       Impact factor: 5.157

6.  SIRT3 deacetylates mitochondrial 3-hydroxy-3-methylglutaryl CoA synthase 2 and regulates ketone body production.

Authors:  Tadahiro Shimazu; Matthew D Hirschey; Lan Hua; Kristin E Dittenhafer-Reed; Bjoern Schwer; David B Lombard; Yu Li; Jakob Bunkenborg; Frederick W Alt; John M Denu; Matthew P Jacobson; Eric Verdin
Journal:  Cell Metab       Date:  2010-12-01       Impact factor: 27.287

7.  Resveratrol upregulated heat shock proteins and extended the survival of G93A-SOD1 mice.

Authors:  Soyoung Han; Jong-Ryoul Choi; Ki Soon Shin; Shin Jung Kang
Journal:  Brain Res       Date:  2012-09-19       Impact factor: 3.252

8.  Mitochondria in sporadic amyotrophic lateral sclerosis.

Authors:  R H Swerdlow; J K Parks; D S Cassarino; P A Trimmer; S W Miller; D J Maguire; J P Sheehan; R S Maguire; G Pattee; V C Juel; L H Phillips; J B Tuttle; J P Bennett; R E Davis; W D Parker
Journal:  Exp Neurol       Date:  1998-09       Impact factor: 5.330

9.  Caprylic triglyceride as a novel therapeutic approach to effectively improve the performance and attenuate the symptoms due to the motor neuron loss in ALS disease.

Authors:  Wei Zhao; Merina Varghese; Prashant Vempati; Anastasiya Dzhun; Alice Cheng; Jun Wang; Dale Lange; Amanda Bilski; Irene Faravelli; Giulio Maria Pasinetti
Journal:  PLoS One       Date:  2012-11-07       Impact factor: 3.240

10.  Peroxisome proliferator activator receptor gamma coactivator-1alpha (PGC-1α) improves motor performance and survival in a mouse model of amyotrophic lateral sclerosis.

Authors:  Wei Zhao; Merina Varghese; Shrishailam Yemul; Yong Pan; Alice Cheng; Paul Marano; Sadiq Hassan; Prashant Vempati; Fei Chen; Xianjuan Qian; Giulio M Pasinetti
Journal:  Mol Neurodegener       Date:  2011-07-19       Impact factor: 14.195
  10 in total
  14 in total

Review 1.  Could Sirtuin Activities Modify ALS Onset and Progression?

Authors:  Bor Luen Tang
Journal:  Cell Mol Neurobiol       Date:  2016-12-10       Impact factor: 5.046

2.  Sirtuin Acetylation and Deacetylation: a Complex Paradigm in Neurodegenerative Disease.

Authors:  Heena Khan; Palak Tiwari; Amarjot Kaur; Thakur Gurjeet Singh
Journal:  Mol Neurobiol       Date:  2021-04-20       Impact factor: 5.590

Review 3.  SIRT1 Promotes Neuronal Fortification in Neurodegenerative Diseases through Attenuation of Pathological Hallmarks and Enhancement of Cellular Lifespan.

Authors:  Priya Mishra; Amit Kumar Mittal; Harikesh Kalonia; Swati Madan; Shampa Ghosh; Jitendra Kumar Sinha; Satyendra Kumar Rajput
Journal:  Curr Neuropharmacol       Date:  2021       Impact factor: 7.363

Review 4.  The Link between Oxidative Stress, Redox Status, Bioenergetics and Mitochondria in the Pathophysiology of ALS.

Authors:  Elena Obrador; Rosario Salvador-Palmer; Rafael López-Blanch; Ali Jihad-Jebbar; Soraya L Vallés; José M Estrela
Journal:  Int J Mol Sci       Date:  2021-06-14       Impact factor: 5.923

Review 5.  A plural role for lipids in motor neuron diseases: energy, signaling and structure.

Authors:  Florent Schmitt; Ghulam Hussain; Luc Dupuis; Jean-Philippe Loeffler; Alexandre Henriques
Journal:  Front Cell Neurosci       Date:  2014-02-20       Impact factor: 5.505

6.  SIRT 1 Overexpression is Associated with Metastasis of Pancreatic Ductal Adenocarcinoma (PDAC) and Promotes Migration and Growth of PDAC Cells.

Authors:  Siqin Li; Hua Hong; Huicheng Lv; Guozhu Wu; Zhigang Wang
Journal:  Med Sci Monit       Date:  2016-05-12

Review 7.  Metabolic Dysfunctions in Amyotrophic Lateral Sclerosis Pathogenesis and Potential Metabolic Treatments.

Authors:  Tesfaye W Tefera; Karin Borges
Journal:  Front Neurosci       Date:  2017-01-10       Impact factor: 4.677

Review 8.  Axonal Degeneration during Aging and Its Functional Role in Neurodegenerative Disorders.

Authors:  Natalia Salvadores; Mario Sanhueza; Patricio Manque; Felipe A Court
Journal:  Front Neurosci       Date:  2017-09-04       Impact factor: 4.677

9.  Tissue-specific deregulation of selected HDACs characterizes ALS progression in mouse models: pharmacological characterization of SIRT1 and SIRT2 pathways.

Authors:  C Valle; I Salvatori; V Gerbino; S Rossi; L Palamiuc; F René; M T Carrì
Journal:  Cell Death Dis       Date:  2014-06-19       Impact factor: 8.469

Review 10.  Function of the SIRT3 mitochondrial deacetylase in cellular physiology, cancer, and neurodegenerative disease.

Authors:  Aneesa Ansari; Md Shahedur Rahman; Subbroto K Saha; Forhad K Saikot; Akash Deep; Ki-Hyun Kim
Journal:  Aging Cell       Date:  2016-09-29       Impact factor: 9.304
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.