Literature DB >> 2385654

Impaired active avoidance responding in rats selectively bred for increased cholinergic function.

D H Overstreet1, A H Rezvani, D S Janowsky.   

Abstract

It was found that the Flinders Sensitive Line (FSL) of rat, selectively bred for increased cholinergic function, performed poorly in a tone-cued two-way active avoidance task in comparison with the control Flinders Restraint Line (FRL) of rat. These findings are consistent with the suggestion that the FSL rats may be a genetic animal model of depression.

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Year:  1990        PMID： 2385654     DOI： 10.1016/0031-9384(90)90097-n

Source DB:  PubMed          Journal:  Physiol Behav        ISSN： 0031-9384


  4 in total

1.  Fear induced neuronal alterations in a genetic model of depression: an fMRI study on awake animals.

Authors:  Wei Huang; Meghan E Heffernan; Zhixin Li; Nanyin Zhang; David H Overstreet; Jean A King
Journal:  Neurosci Lett       Date:  2010-12-04       Impact factor: 3.046

Review 2.  Nicotine receptors and depression: revisiting and revising the cholinergic hypothesis.

Authors:  Yann S Mineur; Marina R Picciotto
Journal:  Trends Pharmacol Sci       Date:  2010-10-19       Impact factor: 14.819

3.  Resting glutamate levels and rapid glutamate transients in the prefrontal cortex of the Flinders Sensitive Line rat: a genetic rodent model of depression.

Authors:  Kevin N Hascup; Erin R Hascup; Michelle L Stephens; Paul E A Glaser; Takashi Yoshitake; Aleksander A Mathé; Greg A Gerhardt; Jan Kehr
Journal:  Neuropsychopharmacology       Date:  2011-04-27       Impact factor: 7.853

4.  ITI-Signals and Prelimbic Cortex Facilitate Avoidance Acquisition and Reduce Avoidance Latencies, Respectively, in Male WKY Rats.

Authors:  Kevin D Beck; Xilu Jiao; Ian M Smith; Catherine E Myers; Kevin C H Pang; Richard J Servatius
Journal:  Front Behav Neurosci       Date:  2014-11-21       Impact factor: 3.558
  4 in total

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