Literature DB >> 23855982

Assessment of TREM2 rs75932628 association with Alzheimer's disease in a population-based sample: the Cache County Study.

Josue D Gonzalez Murcia1, Cameron Schmutz, Caitlin Munger, Ammon Perkes, Aaron Gustin, Michael Peterson, Mark T W Ebbert, Maria C Norton, Joann T Tschanz, Ronald G Munger, Christopher D Corcoran, John S K Kauwe.   

Abstract

Recent studies have identified the rs75932628 (R47H) variant in TREM2 as an Alzheimer's disease risk factor with estimated odds ratio ranging from 2.9 to 5.1. The Cache County Memory Study is a large, population-based sample designed for the study of memory and aging. We genotyped R47H in 2974 samples (427 cases and 2540 control subjects) from the Cache County study using a custom TaqMan assay. We observed 7 heterozygous cases and 12 heterozygous control subjects with an odds ratio of 3.5 (95% confidence interval, 1.3-8.8; p = 0.0076). The minor allele frequency and population attributable fraction for R47H were 0.0029 and 0.004, respectively. This study replicates the association between R47H and Alzheimer's disease risk in a large, population-based sample, and estimates the population frequency and attributable risk of this rare variant.
Copyright © 2013 Elsevier Inc. All rights reserved.

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Keywords:  Alzheimer's disease; Human; R47H; Rare variant; TREM2

Mesh：

Substances：

Year:  2013        PMID： 23855982      PMCID： PMC3779500          DOI： 10.1016/j.neurobiolaging.2013.06.004

Source DB:  PubMed          Journal:  Neurobiol Aging        ISSN： 0197-4580            Impact factor:   4.673


  11 in total

1.  APOE-epsilon4 count predicts age when prevalence of AD increases, then declines: the Cache County Study.

Authors:  J C Breitner; B W Wyse; J C Anthony; K A Welsh-Bohmer; D C Steffens; M C Norton; J T Tschanz; B L Plassman; M R Meyer; I Skoog; A Khachaturian
Journal:  Neurology       Date:  1999-07-22       Impact factor: 9.910

2.  Population-based analysis of Alzheimer's disease risk alleles implicates genetic interactions.

Authors:  Mark T W Ebbert; Perry G Ridge; Andrew R Wilson; Aaron R Sharp; Matthew Bailey; Maria C Norton; JoAnn T Tschanz; Ronald G Munger; Christopher D Corcoran; John S K Kauwe
Journal:  Biol Psychiatry       Date:  2013-08-13       Impact factor: 13.382

3.  Variant TREM2 as risk factor for Alzheimer's disease.

Authors:  Harald Neumann; Mark J Daly
Journal:  N Engl J Med       Date:  2012-11-14       Impact factor: 91.245

4.  TREM2 R47H variant as a risk factor for early-onset Alzheimer's disease.

Authors:  Cyril Pottier; David Wallon; Stephane Rousseau; Anne Rovelet-Lecrux; Anne-Claire Richard; Adeline Rollin-Sillaire; Thierry Frebourg; Dominique Campion; Didier Hannequin
Journal:  J Alzheimers Dis       Date:  2013       Impact factor: 4.472

5.  Variants in triggering receptor expressed on myeloid cells 2 are associated with both behavioral variant frontotemporal lobar degeneration and Alzheimer's disease.

Authors:  Margarita Giraldo; Francisco Lopera; Ashley L Siniard; Jason J Corneveaux; Isabelle Schrauwen; Julian Carvajal; Claudia Muñoz; Manuel Ramirez-Restrepo; Chris Gaiteri; Amanda J Myers; Richard J Caselli; Kenneth S Kosik; Eric M Reiman; Matthew J Huentelman
Journal:  Neurobiol Aging       Date:  2013-04-09       Impact factor: 4.673

6.  Variant of TREM2 associated with the risk of Alzheimer's disease.

Authors:  Thorlakur Jonsson; Hreinn Stefansson; Stacy Steinberg; Ingileif Jonsdottir; Palmi V Jonsson; Jon Snaedal; Sigurbjorn Bjornsson; Johanna Huttenlocher; Allan I Levey; James J Lah; Dan Rujescu; Harald Hampel; Ina Giegling; Ole A Andreassen; Knut Engedal; Ingun Ulstein; Srdjan Djurovic; Carla Ibrahim-Verbaas; Albert Hofman; M Arfan Ikram; Cornelia M van Duijn; Unnur Thorsteinsdottir; Augustine Kong; Kari Stefansson
Journal:  N Engl J Med       Date:  2012-11-14       Impact factor: 91.245

7.  Clinical diagnosis of Alzheimer's disease: report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer's Disease.

Authors:  G McKhann; D Drachman; M Folstein; R Katzman; D Price; E M Stadlan
Journal:  Neurology       Date:  1984-07       Impact factor: 9.910

8.  TREM2 is associated with the risk of Alzheimer's disease in Spanish population.

Authors:  Bruno A Benitez; Breanna Cooper; Pau Pastor; Sheng-Chih Jin; Elena Lorenzo; Sebastian Cervantes; Carlos Cruchaga
Journal:  Neurobiol Aging       Date:  2013-02-05       Impact factor: 4.673

9.  Imputation of sequence variants for identification of genetic risks for Parkinson's disease: a meta-analysis of genome-wide association studies.

Authors:  Michael A Nalls; Vincent Plagnol; Dena G Hernandez; Manu Sharma; Una-Marie Sheerin; Mohamad Saad; J Simón-Sánchez; Claudia Schulte; Suzanne Lesage; Sigurlaug Sveinbjörnsdóttir; Kári Stefánsson; Maria Martinez; John Hardy; Peter Heutink; Alexis Brice; Thomas Gasser; Andrew B Singleton; Nicholas W Wood
Journal:  Lancet       Date:  2011-02-01       Impact factor: 79.321

10.  Common variants at MS4A4/MS4A6E, CD2AP, CD33 and EPHA1 are associated with late-onset Alzheimer's disease.

Authors:  Adam C Naj; Gyungah Jun; Gary W Beecham; Li-San Wang; Badri Narayan Vardarajan; Jacqueline Buros; Paul J Gallins; Joseph D Buxbaum; Gail P Jarvik; Paul K Crane; Eric B Larson; Thomas D Bird; Bradley F Boeve; Neill R Graff-Radford; Philip L De Jager; Denis Evans; Julie A Schneider; Minerva M Carrasquillo; Nilufer Ertekin-Taner; Steven G Younkin; Carlos Cruchaga; John S K Kauwe; Petra Nowotny; Patricia Kramer; John Hardy; Matthew J Huentelman; Amanda J Myers; Michael M Barmada; F Yesim Demirci; Clinton T Baldwin; Robert C Green; Ekaterina Rogaeva; Peter St George-Hyslop; Steven E Arnold; Robert Barber; Thomas Beach; Eileen H Bigio; James D Bowen; Adam Boxer; James R Burke; Nigel J Cairns; Chris S Carlson; Regina M Carney; Steven L Carroll; Helena C Chui; David G Clark; Jason Corneveaux; Carl W Cotman; Jeffrey L Cummings; Charles DeCarli; Steven T DeKosky; Ramon Diaz-Arrastia; Malcolm Dick; Dennis W Dickson; William G Ellis; Kelley M Faber; Kenneth B Fallon; Martin R Farlow; Steven Ferris; Matthew P Frosch; Douglas R Galasko; Mary Ganguli; Marla Gearing; Daniel H Geschwind; Bernardino Ghetti; John R Gilbert; Sid Gilman; Bruno Giordani; Jonathan D Glass; John H Growdon; Ronald L Hamilton; Lindy E Harrell; Elizabeth Head; Lawrence S Honig; Christine M Hulette; Bradley T Hyman; Gregory A Jicha; Lee-Way Jin; Nancy Johnson; Jason Karlawish; Anna Karydas; Jeffrey A Kaye; Ronald Kim; Edward H Koo; Neil W Kowall; James J Lah; Allan I Levey; Andrew P Lieberman; Oscar L Lopez; Wendy J Mack; Daniel C Marson; Frank Martiniuk; Deborah C Mash; Eliezer Masliah; Wayne C McCormick; Susan M McCurry; Andrew N McDavid; Ann C McKee; Marsel Mesulam; Bruce L Miller; Carol A Miller; Joshua W Miller; Joseph E Parisi; Daniel P Perl; Elaine Peskind; Ronald C Petersen; Wayne W Poon; Joseph F Quinn; Ruchita A Rajbhandary; Murray Raskind; Barry Reisberg; John M Ringman; Erik D Roberson; Roger N Rosenberg; Mary Sano; Lon S Schneider; William Seeley; Michael L Shelanski; Michael A Slifer; Charles D Smith; Joshua A Sonnen; Salvatore Spina; Robert A Stern; Rudolph E Tanzi; John Q Trojanowski; Juan C Troncoso; Vivianna M Van Deerlin; Harry V Vinters; Jean Paul Vonsattel; Sandra Weintraub; Kathleen A Welsh-Bohmer; Jennifer Williamson; Randall L Woltjer; Laura B Cantwell; Beth A Dombroski; Duane Beekly; Kathryn L Lunetta; Eden R Martin; M Ilyas Kamboh; Andrew J Saykin; Eric M Reiman; David A Bennett; John C Morris; Thomas J Montine; Alison M Goate; Deborah Blacker; Debby W Tsuang; Hakon Hakonarson; Walter A Kukull; Tatiana M Foroud; Jonathan L Haines; Richard Mayeux; Margaret A Pericak-Vance; Lindsay A Farrer; Gerard D Schellenberg
Journal:  Nat Genet       Date:  2011-04-03       Impact factor: 38.330
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  24 in total

1.  A Weighted Genetic Risk Score Based on Four APOE-Independent Alzheimer's Disease Risk Loci May Supplement APOE E4 for Better Disease Prediction.

Authors:  Chunyu Zhang; Riletemuer Hu; Guohua Zhang; Yan Zhe; Baolige Hu; Juan He; Zhiguang Wang; Xiaokun Qi
Journal:  J Mol Neurosci       Date:  2019-07-25       Impact factor: 3.444

2.  TREM2 variants and risk of Alzheimer's disease: a meta-analysis.

Authors:  Yanjun Lu; Wei Liu; Xiong Wang
Journal:  Neurol Sci       Date:  2015-06-03       Impact factor: 3.307

Review 3.  Microglia-Mediated Neuroprotection, TREM2, and Alzheimer's Disease: Evidence From Optical Imaging.

Authors:  Carlo Condello; Peng Yuan; Jaime Grutzendler
Journal:  Biol Psychiatry       Date:  2017-10-14       Impact factor: 13.382

4.  Genetic Analysis of TREM2 Variants in Tunisian Patients with Alzheimer's Disease.

Authors:  Zied Landoulsi; Mouna Ben Djebara; Imen Kacem; Youssef Sidhom; Rym Kefi; Sonia Abdelhak; Amina Gargouri-Berrechid; Riadh Gouider
Journal:  Med Princ Pract       Date:  2018-05-03       Impact factor: 1.927

5.  The triggering receptor expressed on myeloid cells 2 (TREM2) is associated with enhanced inflammation, neuropathological lesions and increased risk for Alzheimer's dementia.

Authors:  Panos Roussos; Pavel Katsel; Peter Fam; Weilun Tan; Dushyant P Purohit; Vahram Haroutunian
Journal:  Alzheimers Dement       Date:  2014-12-09       Impact factor: 21.566

6.  More evidence for association of a rare TREM2 mutation (R47H) with Alzheimer's disease risk.

Authors:  Samantha L Rosenthal; Mikhil N Bamne; Xingbin Wang; Sarah Berman; Beth E Snitz; William E Klunk; Robert A Sweet; F Yesim Demirci; Oscar L Lopez; M Ilyas Kamboh
Journal:  Neurobiol Aging       Date:  2015-04-25       Impact factor: 4.673

7.  A Missense Variant in TREML2 Reduces Risk of Alzheimer's Disease in a Han Chinese Population.

Authors:  Teng Jiang; Yu Wan; Jun-Shan Zhou; Meng-Shan Tan; Qing Huang; Xi-Chen Zhu; Huan Lu; Hui-Fu Wang; Qi Chen; Lin Tan; Ying-Dong Zhang; Lan Tan; Jin-Tai Yu
Journal:  Mol Neurobiol       Date:  2016-01-21       Impact factor: 5.590

8.  A candidate regulatory variant at the TREM gene cluster associates with decreased Alzheimer's disease risk and increased TREML1 and TREM2 brain gene expression.

Authors:  Minerva M Carrasquillo; Mariet Allen; Jeremy D Burgess; Xue Wang; Samantha L Strickland; Shivani Aryal; Joanna Siuda; Michaela L Kachadoorian; Christopher Medway; Curtis S Younkin; Asha Nair; Chen Wang; Pritha Chanana; Daniel Serie; Thuy Nguyen; Sarah Lincoln; Kimberly G Malphrus; Kevin Morgan; Todd E Golde; Nathan D Price; Charles C White; Philip L De Jager; David A Bennett; Yan W Asmann; Julia E Crook; Ronald C Petersen; Neill R Graff-Radford; Dennis W Dickson; Steven G Younkin; Nilüfer Ertekin-Taner
Journal:  Alzheimers Dement       Date:  2016-12-08       Impact factor: 21.566

9.  TREM2 variant p.R47H as a risk factor for sporadic amyotrophic lateral sclerosis.

Authors:  Janet Cady; Erica D Koval; Bruno A Benitez; Craig Zaidman; Jennifer Jockel-Balsarotti; Peggy Allred; Robert H Baloh; John Ravits; Ericka Simpson; Stanley H Appel; Alan Pestronk; Alison M Goate; Timothy M Miller; Carlos Cruchaga; Matthew B Harms
Journal:  JAMA Neurol       Date:  2014-04       Impact factor: 18.302

10.  Population substructure in Cache County, Utah: the Cache County study.

Authors:  Aaron R Sharp; Perry G Ridge; Matthew H Bailey; Kevin L Boehme; Maria C Norton; JoAnn T Tschanz; Ronald G Munger; Christopher D Corcoran; John S K Kauwe
Journal:  BMC Bioinformatics       Date:  2014-05-28       Impact factor: 3.169
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