Literature DB >> 23852512

Modelling blood flow and metabolism in the piglet brain during hypoxia-ischaemia: simulating pH changes.

Tharindi Hapuarachchi1, Tracy Moroz2, Alan Bainbridge3, David Price3, Ernest Cady3, Esther Baer4, Kevin Broad5, Mojgan Ezzati5, David Thomas6, Xavier Golay6, Nicola J Robertson5, Ilias Tachtsidis4.   

Abstract

We describe the extension of a computational model of blood flow and metabolism in the piglet brain to investigate changes in neonatal intracellular brain pH during hypoxia-ischemia (HI). The model is able to simulate near-infrared spectroscopy (NIRS) and magnetic resonance spectroscopy (MRS) measurements obtained from HI experiments conducted in piglets. We adopt a method of using (31)P-MRS data to estimate of intracellular pH and compare measured pH and oxygenation with their modelled counterparts. We show that both NIRS and MRS measurements are predicted well in the new version of the model.

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Year:  2013        PMID： 23852512      PMCID： PMC4037998          DOI： 10.1007/978-1-4614-7411-1_44

Source DB:  PubMed          Journal:  Adv Exp Med Biol        ISSN： 0065-2598            Impact factor:   2.622


  5 in total

1.  Brain alkaline intracellular pH after neonatal encephalopathy.

Authors:  Nicola J Robertson; Frances M Cowan; I Jane Cox; A David Edwards
Journal:  Ann Neurol       Date:  2002-12       Impact factor: 10.422

2.  A physiological model of cerebral blood flow control.

Authors:  Murad Banaji; Ilias Tachtsidis; David Delpy; Stephen Baigent
Journal:  Math Biosci       Date:  2005-04       Impact factor: 2.144

3.  Phosphorus magnetic resonance spectroscopy 2 h after perinatal cerebral hypoxia-ischemia prognosticates outcome in the newborn piglet.

Authors:  Ernest B Cady; Osuke Iwata; Alan Bainbridge; John S Wyatt; Nicola J Robertson
Journal:  J Neurochem       Date:  2008-09-11       Impact factor: 5.372

4.  The redox state of free nicotinamide-adenine dinucleotide in the cytoplasm and mitochondria of rat liver.

Authors:  D H Williamson; P Lund; H A Krebs
Journal:  Biochem J       Date:  1967-05       Impact factor: 3.857

5.  Computational modelling of the piglet brain to simulate near-infrared spectroscopy and magnetic resonance spectroscopy data collected during oxygen deprivation.

Authors:  Tracy Moroz; Murad Banaji; Nicola J Robertson; Chris E Cooper; Ilias Tachtsidis
Journal:  J R Soc Interface       Date:  2012-01-25       Impact factor: 4.118
  5 in total
  3 in total

Review 1.  The Applicability of Amide Proton Transfer Imaging in the Nervous System: Focus on Hypoxic-Ischemic Encephalopathy in the Neonate.

Authors:  Yang Zheng; Xiaoming Wang
Journal:  Cell Mol Neurobiol       Date:  2017-09-23       Impact factor: 5.046

2.  Monitoring cerebral autoregulation after brain injury: multimodal assessment of cerebral slow-wave oscillations using near-infrared spectroscopy.

Authors:  David Highton; Arnab Ghosh; Ilias Tachtsidis; Jasmina Panovska-Griffiths; Clare E Elwell; Martin Smith
Journal:  Anesth Analg       Date:  2015-07       Impact factor: 6.627

3.  BrainSignals Revisited: Simplifying a Computational Model of Cerebral Physiology.

Authors:  Matthew Caldwell; Tharindi Hapuarachchi; David Highton; Clare Elwell; Martin Smith; Ilias Tachtsidis
Journal:  PLoS One       Date:  2015-05-11       Impact factor: 3.240
  3 in total

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