Fabrice Jardin1, Martin Figeac. 1. Department of Hematology, INSERM U918, IRIB, Centre Henri Becquerel, Rouen, France. jardin@chb.unicancer.fr
Abstract
PURPOSE OF REVIEW: The crucial role of microRNAs (miRNAs) in major biological processes and cancer development has been extensively described. Some stage-specific miRNAs are involved in B-cell differentiation, from the naïve B-cell stage through germinal center maturation. Assuming that lymphoma cells are derived from B cells at different stages of maturation, miRNAs can be considered as both specific markers and putative target genes. Here, we review the most salient recent publications in this field, highlighting the clinical and therapeutic value of miRNAs in lymphomas. RECENT FINDINGS: miRNA array-based experiments have indicated that almost all mature lymphoid malignancies can be characterized by a distinct miRNA profile. Recent works have highlighted the crucial roles of miR-155 and miR-17-92 in the pathogeneses of diffuse large B-cell lymphoma and mantle cell lymphoma, respectively, indicating that they represent promising target genes. Novel mechanisms of miRNA deregulation have also been reported, including recurrent somatic mutations, MYC-driven miRNA repression, and cross-talk with other cells in the microenvironment. SUMMARY: In experimental models, some lymphomas are considered to be addicted to the sustained expression of targetable oncomiRs, such as miR-155 and miR-21. However, despite these results, which provide considerable information regarding lymphoma pathogenesis, the integration of miRNA analysis for lymphoma diagnosis or treatment in daily practice remains challenging.
PURPOSE OF REVIEW: The crucial role of microRNAs (miRNAs) in major biological processes and cancer development has been extensively described. Some stage-specific miRNAs are involved in B-cell differentiation, from the naïve B-cell stage through germinal center maturation. Assuming that lymphoma cells are derived from B cells at different stages of maturation, miRNAs can be considered as both specific markers and putative target genes. Here, we review the most salient recent publications in this field, highlighting the clinical and therapeutic value of miRNAs in lymphomas. RECENT FINDINGS: miRNA array-based experiments have indicated that almost all mature lymphoid malignancies can be characterized by a distinct miRNA profile. Recent works have highlighted the crucial roles of miR-155 and miR-17-92 in the pathogeneses of diffuse large B-cell lymphoma and mantle cell lymphoma, respectively, indicating that they represent promising target genes. Novel mechanisms of miRNA deregulation have also been reported, including recurrent somatic mutations, MYC-driven miRNA repression, and cross-talk with other cells in the microenvironment. SUMMARY: In experimental models, some lymphomas are considered to be addicted to the sustained expression of targetable oncomiRs, such as miR-155 and miR-21. However, despite these results, which provide considerable information regarding lymphoma pathogenesis, the integration of miRNA analysis for lymphoma diagnosis or treatment in daily practice remains challenging.
Authors: Hanne Due; Anna Amanda Schönherz; Laura Ryø; Maria Nascimento Primo; Ditte Starberg Jespersen; Emil Aagaard Thomsen; Anne Stidholt Roug; Min Xiao; Xiaohong Tan; Yuyang Pang; Ken H Young; Martin Bøgsted; Jacob Giehm Mikkelsen; Karen Dybkær Journal: Blood Adv Date: 2019-04-09
Authors: Juan Sandoval; Angel Díaz-Lagares; Rocío Salgado; Octavio Servitje; Fina Climent; Pablo L Ortiz-Romero; Amparo Pérez-Ferriols; Maria P Garcia-Muret; Teresa Estrach; Mar Garcia; Lara Nonell; Manel Esteller; Ramon M Pujol; Blanca Espinet; Fernando Gallardo Journal: J Invest Dermatol Date: 2014-11-18 Impact factor: 8.551