PURPOSE: To evaluate the effect of myopia and age on temporal optic disc margin anatomy within the parapapillary atrophy (PPA) area by use of spectral-domain optical coherence tomography (OCT). METHODS: Fifty young myopic eyes with PPA (myopic PPA group), 50 aged non-myopic eyes with PPA (aged PPA group), and 50 young non-myopic eyes without PPA (control group) were enrolled. High-definition OCT scanning was used to obtain horizontal cross-sectional optic nerve head (ONH) images. By use of these OCT scans we investigated three temporal optic disc margin structures: the configuration of the border tissue of Elschnig; the cross-sectional ONH structure coinciding with the clinically detected optic disc margin; and the integrity of the retinal layers within the PPA area. RESULTS: The distribution of the configuration of the border tissue of Elschnig and the cross-sectional ONH structure coinciding with the clinically detected optic disc margin of the myopic PPA group differed significantly from those of the control group (P < 0.01) whereas those of the aged PPA group did not (P > 0.05). Other than the photoreceptor layer, the retinal layers within the PPA area were more commonly impaired in the myopic PPA group than in the aged PPA group (P < 0.001). CONCLUSIONS: Myopia and aging led to different structural changes in temporal optic disc margin anatomy within the PPA area. This finding implies that different mechanisms may underlie myopic and age-related PPA development.
PURPOSE: To evaluate the effect of myopia and age on temporal optic disc margin anatomy within the parapapillary atrophy (PPA) area by use of spectral-domain optical coherence tomography (OCT). METHODS: Fifty young myopic eyes with PPA (myopic PPA group), 50 aged non-myopic eyes with PPA (aged PPA group), and 50 young non-myopic eyes without PPA (control group) were enrolled. High-definition OCT scanning was used to obtain horizontal cross-sectional optic nerve head (ONH) images. By use of these OCT scans we investigated three temporal optic disc margin structures: the configuration of the border tissue of Elschnig; the cross-sectional ONH structure coinciding with the clinically detected optic disc margin; and the integrity of the retinal layers within the PPA area. RESULTS: The distribution of the configuration of the border tissue of Elschnig and the cross-sectional ONH structure coinciding with the clinically detected optic disc margin of the myopic PPA group differed significantly from those of the control group (P < 0.01) whereas those of the aged PPA group did not (P > 0.05). Other than the photoreceptor layer, the retinal layers within the PPA area were more commonly impaired in the myopic PPA group than in the aged PPA group (P < 0.001). CONCLUSIONS:Myopia and aging led to different structural changes in temporal optic disc margin anatomy within the PPA area. This finding implies that different mechanisms may underlie myopic and age-related PPA development.
Authors: Christopher C Teng; Carlos Gustavo De Moraes; Tiago S Prata; Craig A Liebmann; Celso Tello; Robert Ritch; Jeffrey M Liebmann Journal: Ophthalmology Date: 2011-09-01 Impact factor: 12.079
Authors: Alexandre S C Reis; Glen P Sharpe; Hongli Yang; Marcelo T Nicolela; Claude F Burgoyne; Balwantray C Chauhan Journal: Ophthalmology Date: 2012-01-04 Impact factor: 12.079
Authors: Nicholas G Strouthidis; Hongli Yang; Juan F Reynaud; Jonathan L Grimm; Stuart K Gardiner; Brad Fortune; Claude F Burgoyne Journal: Invest Ophthalmol Vis Sci Date: 2009-05-14 Impact factor: 4.799
Authors: Patricia Isabel C Manalastas; Akram Belghith; Robert N Weinreb; Jost B Jonas; Min Hee Suh; Adeleh Yarmohammadi; Felipe A Medeiros; Christopher A Girkin; Jeffrey M Liebmann; Linda M Zangwill Journal: Am J Ophthalmol Date: 2018-05-09 Impact factor: 5.258