Literature DB >> 23851185

An endogenous aryl hydrocarbon receptor ligand inhibits proliferation and migration of human ovarian cancer cells.

Kai Wang1,2, Yan Li2, Yi-Zhou Jiang2, Cai-Feng Dai2,3, Manish S Patankar2, Jia-Sheng Song4, Jing Zheng2,5.   

Abstract

The aryl hydrocarbon receptor (AhR), a ligand-activated transcription factor mediates many biological processes. Herein, we investigated if 2-(1'H-indole-3'-carbonyl)-thiazole-4-carboxylic acid methyl ester (ITE, an endogenous AhR ligand) regulated proliferation and migration of human ovarian cancer cells via AhR. We found that AhR was widely present in many histotypes of ovarian cancer tissues. ITE suppressed OVCAR-3 cell proliferation and SKOV-3 cell migration in vitro, which were blocked by AhR knockdown. ITE also suppressed OVCAR-3 cell growth in mice. These data suggest that the ITE might potentially be used for therapeutic intervention for at least a subset of human ovarian cancer.
Copyright © 2013 Elsevier Ireland Ltd. All rights reserved.

Entities:  

Keywords:  Aryl hydrocarbon receptor; Growth; ITE; Ovarian cancer cells

Mesh：

Substances：

Year:  2013        PMID： 23851185      PMCID： PMC3781955          DOI： 10.1016/j.canlet.2013.06.026

Source DB:  PubMed          Journal:  Cancer Lett        ISSN： 0304-3835            Impact factor:   8.679


  40 in total

1.  Dioxin exposure and cancer risk: a 15-year mortality study after the "Seveso accident".

Authors:  P A Bertazzi; C Zocchetti; S Guercilena; D Consonni; A Tironi; M T Landi; A C Pesatori
Journal:  Epidemiology       Date:  1997-11       Impact factor: 4.822

2.  Estrogen and aryl hydrocarbon receptor expression and crosstalk in human Ishikawa endometrial cancer cells.

Authors:  M Wormke; E Castro-Rivera; I Chen; S Safe
Journal:  J Steroid Biochem Mol Biol       Date:  2000-04       Impact factor: 4.292

3.  A ligand for the aryl hydrocarbon receptor isolated from lung.

Authors:  Jiasheng Song; Margaret Clagett-Dame; Richard E Peterson; Mark E Hahn; William M Westler; Rafal R Sicinski; Hector F DeLuca
Journal:  Proc Natl Acad Sci U S A       Date:  2002-10-30       Impact factor: 11.205

4.  Expression of p53 in cisplatin-resistant ovarian cancer cell lines: modulation with the novel platinum analogue (1R, 2R-diaminocyclohexane)(trans-diacetato)(dichloro)-platinum(IV).

Authors:  G S Hagopian; G B Mills; A R Khokhar; R C Bast; Z H Siddik
Journal:  Clin Cancer Res       Date:  1999-03       Impact factor: 12.531

5.  Overexpression of aryl hydrocarbon receptor in human lung carcinomas.

Authors:  Pinpin Lin; Han Chang; Wen-Tin Tsai; Meng-Hsiang Wu; Yung-Shen Liao; Jung-Ta Chen; Jang-Ming Su
Journal:  Toxicol Pathol       Date:  2003 Jan-Feb       Impact factor: 1.902

Review 6.  Cross-talk of dioxin and estrogen receptor signals through the ubiquitin system.

Authors:  Fumiaki Ohtake; Yoshiaki Fujii-Kuriyama; Kaname Kawajiri; Shigeaki Kato
Journal:  J Steroid Biochem Mol Biol       Date:  2011-03-21       Impact factor: 4.292

7.  A critical role for MAP kinases in the control of Ah receptor complex activity.

Authors:  Zongqing Tan; Mingya Huang; Alvaro Puga; Ying Xia
Journal:  Toxicol Sci       Date:  2004-07-22       Impact factor: 4.849

Review 8.  Estrogens and epithelial ovarian cancer.

Authors:  Séverine Cunat; Pascale Hoffmann; Pascal Pujol
Journal:  Gynecol Oncol       Date:  2004-07       Impact factor: 5.482

9.  Activation of mitogen-activated protein kinases (MAPKs) by aromatic hydrocarbons: role in the regulation of aryl hydrocarbon receptor (AHR) function.

Authors:  Zongqing Tan; Xiaoqing Chang; Alvaro Puga; Ying Xia
Journal:  Biochem Pharmacol       Date:  2002-09       Impact factor: 5.858

Review 10.  Dioxin revisited: developments since the 1997 IARC classification of dioxin as a human carcinogen.

Authors:  Kyle Steenland; Pier Bertazzi; Andrea Baccarelli; Manolis Kogevinas
Journal:  Environ Health Perspect       Date:  2004-09       Impact factor: 9.031
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  31 in total

1.  Preeclampsia does not alter vascular growth and expression of CD31 and vascular endothelial cadherin in human placentas.

Authors:  Yan Li; Ying-Jie Zhao; Qing-Yun Zou; Kevin Zhang; Yan-Ming Wu; Chi Zhou; Kai Wang; Jing Zheng
Journal:  J Histochem Cytochem       Date:  2014-10-31       Impact factor: 2.479

2.  Roles of aryl hydrocarbon receptor in endothelial angiogenic responses†.

Authors:  Yan Li; Chi Zhou; Wei Lei; Kai Wang; Jing Zheng
Journal:  Biol Reprod       Date:  2020-10-29       Impact factor: 4.285

3.  2,3,7,8-Tetrachlorodibenzo-p-dioxin differentially suppresses angiogenic responses in human placental vein and artery endothelial cells.

Authors:  Yan Li; Kai Wang; Qing-Yun Zou; Ronald R Magness; Jing Zheng
Journal:  Toxicology       Date:  2015-08-11       Impact factor: 4.221

4.  ITE inhibits growth of human pulmonary artery endothelial cells.

Authors:  Ling-Pin Pang; Yan Li; Qing-Yun Zou; Chi Zhou; Wei Lei; Jing Zheng; Shi-An Huang
Journal:  Exp Lung Res       Date:  2017-10       Impact factor: 2.459

5.  2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) inhibits human ovarian cancer cell proliferation.

Authors:  Yan Li; Kai Wang; Yi-Zhou Jiang; Xin-Wen Chang; Cai-Feng Dai; Jing Zheng
Journal:  Cell Oncol (Dordr)       Date:  2014-11-18       Impact factor: 6.730

6.  The putative endogenous AHR ligand ITE reduces JAG1 and associated NOTCH1 signaling in triple negative breast cancer cells.

Authors:  Sean A Piwarski; Chelsea Thompson; Ateeq R Chaudhry; James Denvir; Donald A Primerano; Jun Fan; Travis B Salisbury
Journal:  Biochem Pharmacol       Date:  2020-02-04       Impact factor: 5.858

Review 7.  The Aryl Hydrocarbon Receptor: A Key Bridging Molecule of External and Internal Chemical Signals.

Authors:  Jijing Tian; Yu Feng; Hualing Fu; Heidi Qunhui Xie; Joy Xiaosong Jiang; Bin Zhao
Journal:  Environ Sci Technol       Date:  2015-08-10       Impact factor: 9.028

8.  Expression of aryl hydrocarbon receptor in relation to p53 status and clinicopathological parameters in breast cancer.

Authors:  Zheng-Dong Li; Kai Wang; Xin-Wei Yang; Zhi-Gang Zhuang; Jian-Jun Wang; Xiao-Wen Tong
Journal:  Int J Clin Exp Pathol       Date:  2014-10-15

9.  ITE Suppresses Angiogenic Responses in Human Artery and Vein Endothelial Cells: Differential Roles of AhR.

Authors:  Yan Li; Kai Wang; Qing-Yun Zou; Yi-Zhou Jiang; Chi Zhou; Jing Zheng
Journal:  Reprod Toxicol       Date:  2017-10-03       Impact factor: 3.143

Review 10.  Regulation of the Immune Response by the Aryl Hydrocarbon Receptor.

Authors:  Cristina Gutiérrez-Vázquez; Francisco J Quintana
Journal:  Immunity       Date:  2018-01-16       Impact factor: 31.745
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