| Literature DB >> 23850580 |
Beatriz Tavira1, Juan Gómez, Francisco Ortega, Salvador Tranche, Carmen Díaz-Corte, Francisco Alvarez, Alberto Ortiz, Fernando Santos, María D Sánchez-Niño, Eliecer Coto.
Abstract
A total of 569 individuals aged 55-85 and Caucasian were genotyped for SNP rs10927887 in the Ka renal chloride channel gene (CLCNKA). The following variables were significantly associated with an estimated glomerular filtration rate of (eGFR) <60 ml/min./1.73 m(2): age, type 2 diabetes, total cholesterol, LDL-cholesterol, and the CLCNKA GG genotype (p=0.03; OR=1.65, 95% CI=1.04-2.62). This novel finding could partly explain the reported greater risk of heart failure linked to the CLCNKA SNP, but requires confirmation on other populations.Entities:
Keywords: BMI; CKD; CLCNKA; Gene polymorphisms; Glomerular filtration; HSPB7; HTA; K(a) renal chloride channel gene; MDRD; Modification of Diet in Renal Disease; RFLP; Renal function; SNPs; T2DM; body mass index; chronic kidney disease; eGFR; estimated glomerular filtration rate; heat shock protein B7 gene; hypertension; restriction fragment length polymorphism; single nucleotide polymorphisms; type 2 diabetes mellitus
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Year: 2013 PMID： 23850580 DOI： 10.1016/j.gene.2013.06.055
Source DB: PubMed Journal: Gene ISSN： 0378-1119 Impact factor: 3.688