| Literature DB >> 23850191 |
Menno J Oudhoff1, Spencer A Freeman, Amber L Couzens, Frann Antignano, Ekaterina Kuznetsova, Paul H Min, Jeffrey P Northrop, Bernhard Lehnertz, Dalia Barsyte-Lovejoy, Masoud Vedadi, Cheryl H Arrowsmith, Hiroshi Nishina, Michael R Gold, Fabio M V Rossi, Anne-Claude Gingras, Colby Zaph.
Abstract
Methylation of nonhistone proteins is emerging as a regulatory mechanism to control protein function. Set7 (Setd7) is a SET-domain-containing lysine methyltransferase that methylates and alters function of a variety of proteins in vitro, but the in vivo relevance has not been established. We found that Set7 is a modifier of the Hippo pathway. Mice that lack Set7 have a larger progenitor compartment in the intestine, coinciding with increased expression of Yes-associated protein (Yap) target genes. Mechanistically, monomethylation of lysine 494 of Yap is critical for cytoplasmic retention. These results identify a methylation-dependent checkpoint in the Hippo pathway.Entities:
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Year: 2013 PMID： 23850191 DOI： 10.1016/j.devcel.2013.05.025
Source DB: PubMed Journal: Dev Cell ISSN： 1534-5807 Impact factor: 12.270