Literature DB >> 23850153

The hallmarks of cancer and the radiation oncologist: updating the 5Rs of radiobiology.

J S Good1, K J Harrington.   

Abstract

A comprehensive, mechanistic understanding of radiobiological phenomena that can be integrated within the broader context of cancer biology offers the prospect of transforming clinical practice in radiation oncology. In this review, we revisit the six established biological hallmarks of cancer and examine how they have provided insights into novel therapeutic strategies. In addition, we discuss the potential of two emerging hallmarks to continue to expand our understanding beyond the narrow confines of the traditional 5Rs of radiobiology.
Copyright © 2013 The Royal College of Radiologists. Published by Elsevier Ltd. All rights reserved.

Entities:  

Keywords:  Radiobiology; radiosensitivity; redistribution; reoxygenation; repair; repopulation

Mesh：

Year:  2013        PMID： 23850153     DOI： 10.1016/j.clon.2013.06.009

Source DB:  PubMed          Journal:  Clin Oncol (R Coll Radiol)        ISSN： 0936-6555            Impact factor:   4.126


  25 in total

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Authors:  P Sminia; B A Westerman
Journal:  Br J Clin Pharmacol       Date:  2016-02-08       Impact factor: 4.335

Review 2.  Opportunities and challenges of radiotherapy for treating cancer.

Authors:  Dörthe Schaue; William H McBride
Journal:  Nat Rev Clin Oncol       Date:  2015-06-30       Impact factor: 66.675

3.  Equating salivary lactate dehydrogenase (LDH) with LDH-5 expression in patients with oral squamous cell carcinoma: An insight into metabolic reprogramming of cancer cell as a predictor of aggressive phenotype.

Authors:  Tajindra Singh Saluja; Anita Spadigam; Anita Dhupar; Shaheen Syed
Journal:  Tumour Biol       Date:  2015-11-15

4.  Application of gene polymorphisms to predict the sensitivity of patients with locally advanced non-small cell lung cancer undergoing chemoradiotherapy.

Authors:  Yue Zhao; Yun Xie; Dianjun Jia; Chiluan Ma; Dongdong Wei; Xiaoyu Zhang
Journal:  Am J Transl Res       Date:  2021-06-15       Impact factor: 4.060

5.  Elevated VEGF-A & PLGF concentration in aqueous humor of patients with uveal melanoma following Iodine-125 plaque radiotherapy.

Authors:  Meng-Xi Chen; Yue-Ming Liu; Yang Li; Xuan Yang; Wen-Bin Wei
Journal:  Int J Ophthalmol       Date:  2020-04-18       Impact factor: 1.779

Review 6.  The tumour microenvironment after radiotherapy: mechanisms of resistance and recurrence.

Authors:  Holly E Barker; James T E Paget; Aadil A Khan; Kevin J Harrington
Journal:  Nat Rev Cancer       Date:  2015-07       Impact factor: 60.716

7.  Role of neutrophil extracellular traps in radiation resistance of invasive bladder cancer.

Authors:  Surashri Shinde-Jadhav; Jose Joao Mansure; Roni F Rayes; Gautier Marcq; Mina Ayoub; Rodrigo Skowronski; Ronald Kool; France Bourdeau; Fadi Brimo; Jonathan Spicer; Wassim Kassouf
Journal:  Nat Commun       Date:  2021-05-13       Impact factor: 14.919

8.  Pharmacological Inhibition of HSP90 Radiosensitizes Head and Neck Squamous Cell Carcinoma Xenograft by Inhibition of DNA Damage Repair, Nucleotide Metabolism, and Radiation-Induced Tumor Vasculogenesis.

Authors:  Sarwat Naz; Andrew J Leiker; Rajani Choudhuri; Olivia Preston; Anastasia L Sowers; Sangeeta Gohain; Janet Gamson; Askale Mathias; Carter Van Waes; John A Cook; James B Mitchell
Journal:  Int J Radiat Oncol Biol Phys       Date:  2021-04-07       Impact factor: 8.013

9.  Nimotuzumab enhances radiation sensitivity of NSCLC H292 cells in vitro by blocking epidermal growth factor receptor nuclear translocation and inhibiting radiation-induced DNA damage repair.

Authors:  Kai Teng; Yong Zhang; Xiaoyan Hu; Yihui Ding; Rui Gong; Li Liu
Journal:  Onco Targets Ther       Date:  2015-04-13       Impact factor: 4.147

10.  Clinical development of new drug-radiotherapy combinations.

Authors:  Ricky A Sharma; Ruth Plummer; Julie K Stock; Tessa A Greenhalgh; Ozlem Ataman; Stephen Kelly; Robert Clay; Richard A Adams; Richard D Baird; Lucinda Billingham; Sarah R Brown; Sean Buckland; Helen Bulbeck; Anthony J Chalmers; Glen Clack; Aaron N Cranston; Lars Damstrup; Roberta Ferraldeschi; Martin D Forster; Julian Golec; Russell M Hagan; Emma Hall; Axel-R Hanauske; Kevin J Harrington; Tom Haswell; Maria A Hawkins; Tim Illidge; Hazel Jones; Andrew S Kennedy; Fiona McDonald; Thorsten Melcher; James P B O'Connor; John R Pollard; Mark P Saunders; David Sebag-Montefiore; Melanie Smitt; John Staffurth; Ian J Stratford; Stephen R Wedge
Journal:  Nat Rev Clin Oncol       Date:  2016-06-01       Impact factor: 66.675
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