| Literature DB >> 23849986 |
Anat Gafter-Gvili1, Mical Paul, Hanna Bernstine, Liat Vidal, Ron Ram, Pia Raanani, Moshe Yeshurun, Boaz Tadmor, Leonard Leibovici, Ofer Shpilberg, David Groshar.
Abstract
We assessed the performance of PET/CT for diagnosis and management of infections in high-risk hematological cancer patients with persistent febrile neutropenia in a prospective study. (18)F-FDG PET/CT with contrast-enhanced CT was performed on day 5-7 of persistent fever. Between 2008 and 2011, 91 PET/CT examinations were performed for different episodes in 79 patients, resulting in 117 diagnoses. The sensitivity of the PET/CT was 79.8% (71/89) compared to 51.7% (46/89) with chest/sinus CT alone. Specificities were 32.14% (9/28) vs. 42.85% (12/28), respectively. PET/CT resulted in a change from the pre-test diagnosis in 63/91 (69%) of episodes and in modification of patients' management in 46/91 (55%). PET/CT was beneficial in diagnosing abdominal infections. PET/CT has a potential role in the diagnostic evaluation of patients with persistent febrile neutropenia.Entities:
Keywords: FDG; Febrile neutropenia; Hematological malignancies; Invasive fungal infections; PET/CT
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Year: 2013 PMID： 23849986 DOI： 10.1016/j.leukres.2013.06.025
Source DB: PubMed Journal: Leuk Res ISSN： 0145-2126 Impact factor: 3.156