Lihong Zhu1, Ningyu Wang. 1. Department of Otolaryngology & Head and Neck Surgery, Beijing Chaoyang Hospital, Capital Medical University, Gongti Nanlu No.8, Chaoyang District, Beijing 100020, PR China.
Abstract
BACKGROUND: We performed a meta-analysis to evaluate the value of (18)F-fluorodeoxyglucose positron emission tomography-computed tomography ((18)FDG PET-CT) for the detection of primary sites in patients with cervical nodal metastases of unknown origin. METHODS: Studies were systematically searched for relevant PET-CT original articles in the MEDLINE and EMBASE databases. We calculated the primary tumor detection rate, sensitivity, specificity, and likelihood ratios for (18)FDG PET-CT. We also constructed the hierarchic summary receiver operating characteristic curve for (18)FDG PET-CT. RESULTS: This present study analyzed a total of 7 selected studies (246 patients). The primary tumor detection rate, sensitivity and specificity of PET-CT were 0.44 (95% confidence interval [CI] = 0.31-0.58), 0.97 (95% CI = 0.63-0.99), and 0.68 (95% CI = 0.49-0.83). Area under the curve was 0.83 (95% CI = 0.80-0.86). CONCLUSIONS: (18)FDG PET-CT has high sensitivity and low specificity for the detection of primary sites in patients with cervical nodal metastases of unknown origin. Crown
BACKGROUND: We performed a meta-analysis to evaluate the value of (18)F-fluorodeoxyglucose positron emission tomography-computed tomography ((18)FDG PET-CT) for the detection of primary sites in patients with cervical nodal metastases of unknown origin. METHODS: Studies were systematically searched for relevant PET-CT original articles in the MEDLINE and EMBASE databases. We calculated the primary tumor detection rate, sensitivity, specificity, and likelihood ratios for (18)FDG PET-CT. We also constructed the hierarchic summary receiver operating characteristic curve for (18)FDG PET-CT. RESULTS: This present study analyzed a total of 7 selected studies (246 patients). The primary tumor detection rate, sensitivity and specificity of PET-CT were 0.44 (95% confidence interval [CI] = 0.31-0.58), 0.97 (95% CI = 0.63-0.99), and 0.68 (95% CI = 0.49-0.83). Area under the curve was 0.83 (95% CI = 0.80-0.86). CONCLUSIONS: (18)FDG PET-CT has high sensitivity and low specificity for the detection of primary sites in patients with cervical nodal metastases of unknown origin. Crown
Authors: Jon Cacicedo; Arturo Navarro; Olga Del Hoyo; Alfonso Gomez-Iturriaga; Filippo Alongi; Jose A Medina; Olgun Elicin; Andrea Skanjeti; Francesco Giammarile; Pedro Bilbao; Francisco Casquero; Berardino de Bari; Alan Dal Pra Journal: Br J Radiol Date: 2016-08-02 Impact factor: 3.039
Authors: Sungmin Woo; Anton S Becker; Richard K G Do; Heiko Schöder; Hedvig Hricak; H Alberto Vargas Journal: Eur J Cancer Date: 2021-11-02 Impact factor: 9.162