Literature DB >> 23848233

Cycloforskamide, a cytotoxic macrocyclic peptide from the sea slug Pleurobranchus forskalii.

Karen Co Tan1, Toshiyuki Wakimoto, Kentaro Takada, Takashi Ohtsuki, Nahoko Uchiyama, Yukihiro Goda, Ikuro Abe.   

Abstract

A macrocylic dodecapeptide, cycloforskamide, was isolated from the sea slug Pleurobranchus forskalii, collected off Ishigaki Island, Japan. Its planar structure was deduced by extensive NMR analyses and was further confirmed by MS/MS fragmentation analyses. Finally, the absolute configuration was determined by total hydrolysis and chiral-phase gas chromatographic analysis. This novel dodecapeptide contains three d-amino acids and three thiazoline heterocycles and exhibits cytotoxicity against murine leukemia P388 cells, with an IC50 of 5.8 μM.

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Year:  2013        PMID： 23848233     DOI： 10.1021/np400404r

Source DB:  PubMed          Journal:  J Nat Prod        ISSN： 0163-3864            Impact factor:   4.050


  7 in total

Review 1.  Marine Mollusk-Derived Agents with Antiproliferative Activity as Promising Anticancer Agents to Overcome Chemotherapy Resistance.

Authors:  Maria Letizia Ciavatta; Florence Lefranc; Marianna Carbone; Ernesto Mollo; Margherita Gavagnin; Tania Betancourt; Ramesh Dasari; Alexander Kornienko; Robert Kiss
Journal:  Med Res Rev       Date:  2016-12-07       Impact factor: 12.944

Review 2.  Bioactive Compounds from Marine Heterobranchs.

Authors:  Conxita Avila; Carlos Angulo-Preckler
Journal:  Mar Drugs       Date:  2020-12-21       Impact factor: 5.118

Review 3.  Natural Proline-Rich Cyclopolypeptides from Marine Organisms: Chemistry, Synthetic Methodologies and Biological Status.

Authors:  Wan-Yin Fang; Rajiv Dahiya; Hua-Li Qin; Rita Mourya; Sandeep Maharaj
Journal:  Mar Drugs       Date:  2016-10-26       Impact factor: 5.118

Review 4.  N-Propargylamines: versatile building blocks in the construction of thiazole cores.

Authors:  S Arshadi; E Vessally; L Edjlali; R Hosseinzadeh-Khanmiri; E Ghorbani-Kalhor
Journal:  Beilstein J Org Chem       Date:  2017-03-30       Impact factor: 2.883

Review 5.  Natural Bioactive Thiazole-Based Peptides from Marine Resources: Structural and Pharmacological Aspects.

Authors:  Rajiv Dahiya; Sunita Dahiya; Neeraj Kumar Fuloria; Suresh Kumar; Rita Mourya; Suresh V Chennupati; Satish Jankie; Hemendra Gautam; Sunil Singh; Sanjay Kumar Karan; Sandeep Maharaj; Shivkanya Fuloria; Jyoti Shrivastava; Alka Agarwal; Shamjeet Singh; Awadh Kishor; Gunjan Jadon; Ajay Sharma
Journal:  Mar Drugs       Date:  2020-06-24       Impact factor: 5.118

6.  Nicotinic Acetylcholine Receptor Partial Antagonist Polyamides from Tunicates and Their Predatory Sea Slugs.

Authors:  Noemi D Paguigan; Jortan O Tun; Lee S Leavitt; Zhenjian Lin; Kevin Chase; Cheryl Dowell; Cassandra E Deering-Rice; Albebson L Lim; Manju Karthikeyan; Ronald W Hughen; Jie Zhang; Randall T Peterson; Christopher A Reilly; Alan R Light; Shrinivasan Raghuraman; J Michael McIntosh; Baldomero M Olivera; Eric W Schmidt
Journal:  ACS Chem Neurosci       Date:  2021-07-02       Impact factor: 5.780

Review 7.  The Potential of Indonesian Heterobranchs Found around Bunaken Island for the Production of Bioactive Compounds.

Authors:  Katja M Fisch; Cora Hertzer; Nils Böhringer; Zerlina G Wuisan; Dorothee Schillo; Robert Bara; Fontje Kaligis; Heike Wägele; Gabriele M König; Till F Schäberle
Journal:  Mar Drugs       Date:  2017-12-07       Impact factor: 5.118
  7 in total

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