Literature DB >> 2384805

Validation studies of iodine-123-iodoamphetamine as a cerebral blood flow tracer using emission tomography.

J H Greenberg1, M Kushner, M Rango, A Alavi, M Reivich.   

Abstract

We studied the radioisotope iodine-123-iodoamphetamine ([123I]IMP) and its performance in single-photon emission computed tomographic (SPECT) studies of cerebral blood flow (CBF). In seven normal volunteers, IMP/SPECT CBF measurements were calculated using a two-compartment model and were compared with the results of CBF measurements utilizing (O15)-H2O and positron emission tomography (PET). Calculated mean PET CBF was 57.6 ml/100 g/min while the SPECT CBF value was 47.3 ml/100 g/min. The response of IMP/SPECT CBF to alterations in arterial PaCO2 was studied in hypo-, eu- and hypercarbic subjects. SPECT CBF values showed a reactivity of 1.03 ml/100 g/min per mmHg PaCO2 change. These results show that the IMP/SPECT CBF technique may be used for quantitative imaging of CBF in man. They provide further support for IMP as a CBF tracer.

Entities:  

Mesh：

Substances：

Year:  1990        PMID： 2384805

Source DB:  PubMed          Journal:  J Nucl Med        ISSN： 0161-5505            Impact factor:   10.057


  10 in total

1.  Clinical application of arterial spin-labeling MR imaging in patients with carotid stenosis: quantitative comparative study with single-photon emission CT.

Authors:  Y Uchihashi; K Hosoda; I Zimine; A Fujita; M Fujii; K Sugimura; E Kohmura
Journal:  AJNR Am J Neuroradiol       Date:  2011-07-14       Impact factor: 3.825

2.  Quantitative measurement of regional cerebral blood flow with flow-sensitive alternating inversion recovery imaging: comparison with [iodine 123]-iodoamphetamin single photon emission CT.

Authors:  Ali Syed Arbab; Shigeki Aoki; Keiji Toyama; Nobuhiko Miyazawa; Hiroshi Kumagai; Takako Umeda; Takao Arai; Tsutomu Araki; Hiroyuki Kabasawa; Yoshiyuki Takahashi
Journal:  AJNR Am J Neuroradiol       Date:  2002-03       Impact factor: 3.825

3.  Error analysis of autoradiography method for measurement of cerebral blood flow by 123I-IMP brain SPECT: a comparison study with table look-up method and microsphere model method.

Authors:  H Ito; K Ishii; H Atsumi; Y Inukai; S Abe; M Sato; T Kinoshita; R Kawashima; S Ono; H Fukuda
Journal:  Ann Nucl Med       Date:  1995-11       Impact factor: 2.668

Review 4.  PET and SPECT imaging of the brain: a review on the current status of nuclear medicine in Japan.

Authors:  Tomohiro Kaneta
Journal:  Jpn J Radiol       Date:  2020-02-10       Impact factor: 2.374

5.  Quantifying regional cerebral blood flow with N-isopropyl-p[123I]iodoamphetamine by ring-type single-photon emission computed tomography: validity of a method to estimate early reference value by means of regional brain time-activity curve.

Authors:  N Takahashi
Journal:  Ann Nucl Med       Date:  1994-11       Impact factor: 2.668

6.  Validation of the dual-table autoradiographic method to quantify two sequential rCBFs in a single SPET session with N-isopropyl-[123I] p-iodoamphetamine.

Authors:  Sadahiko Nishizawa; Hidehiro Iida; Tatsuro Tsuchida; Harumi Ito; Junji Konishi; Yoshiharu Yonekura
Journal:  Eur J Nucl Med Mol Imaging       Date:  2003-05-07       Impact factor: 9.236

7.  Correlation of Asymmetry Indices Measured by Arterial Spin-Labeling MR Imaging and SPECT in Patients with Crossed Cerebellar Diaschisis.

Authors:  K M Kang; C-H Sohn; B S Kim; Y I Kim; S H Choi; T J Yun; J-h Kim; S-W Park; G J Cheon; M H Han
Journal:  AJNR Am J Neuroradiol       Date:  2015-07-30       Impact factor: 3.825

8.  Time-of-Flight MR Angiography for Detection of Cerebral Hyperperfusion Syndrome after Superficial Temporal Artery-Middle Cerebral Artery Anastomosis in Moyamoya Disease.

Authors:  K Sato; M Yamada; H Kuroda; D Yamamoto; Y Asano; Y Inoue; K Fujii; T Kumabe
Journal:  AJNR Am J Neuroradiol       Date:  2016-03-03       Impact factor: 3.825

9.  A method to quantitate cerebral blood flow using a rotating gamma camera and iodine-123 iodoamphetamine with one blood sampling.

Authors:  H Iida; H Itoh; P M Bloomfield; M Munaka; S Higano; M Murakami; A Inugami; S Eberl; Y Aizawa; I Kanno
Journal:  Eur J Nucl Med       Date:  1994-10

10.  Error analysis of table look-up method for cerebral blood flow measurement by 123I-IMP brain SPECT: comparison with conventional microsphere model method.

Authors:  H Ito; K Ishii; H Atsumi; T Kinoshita; R Kawashima; S Ono; S Yoshioka; H Iida; K Uemura; H Fukuda
Journal:  Ann Nucl Med       Date:  1995-05       Impact factor: 2.668
  10 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.