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Literature DB >> 23847689

HIV-1 Nef: hacker of the host cell.

Shailendra K Saxena¹, Gaurav Shrivastava, Sneham Tiwari, Madhavan Pn Nair.

Abstract

Entities: CellLine Chemical Disease Gene Species

Keywords: CD4; HIV-1; MHC-I downregulation; Nef; T-cell activation; apoptosis; host cellular proteins; p21-activated kinase 2; p53 tumor suppressing protein

Year: 2012 PMID： 23847689 PMCID： PMC3705768 DOI： 10.2217/fvl.11.146

Source DB: PubMed Journal: Future Virol ISSN： 1746-0794 Impact factor: 1.831

× No keyword cloud information.

15 in total

1. HIV-1 Nef associated PAK and PI3-kinases stimulate Akt-independent Bad-phosphorylation to induce anti-apoptotic signals.

Authors: D Wolf; V Witte; B Laffert; K Blume; E Stromer; S Trapp; P d'Aloja; A Schürmann; A S Baur
Journal: Nat Med Date: 2001-11 Impact factor: 53.440

Review 2. HIV-1 accessory proteins--ensuring viral survival in a hostile environment.

Authors: Michael H Malim; Michael Emerman
Journal: Cell Host Microbe Date: 2008-06-12 Impact factor: 21.023

3. Dynamic evolution of the human immunodeficiency virus type 1 pathogenic factor, Nef.

Authors: Eduardo O'Neill; Lillian S Kuo; John F Krisko; Diana R Tomchick; J Victor Garcia; John L Foster
Journal: J Virol Date: 2006-02 Impact factor: 5.103

4. Nef-mediated suppression of T cell activation was lost in a lentiviral lineage that gave rise to HIV-1.

Authors: Michael Schindler; Jan Münch; Olaf Kutsch; Hui Li; Mario L Santiago; Frederic Bibollet-Ruche; Michaela C Müller-Trutwin; Francis J Novembre; Martine Peeters; Valerie Courgnaud; Elizabeth Bailes; Pierre Roques; Donald L Sodora; Guido Silvestri; Paul M Sharp; Beatrice H Hahn; Frank Kirchhoff
Journal: Cell Date: 2006-06-16 Impact factor: 41.582

5. HIV-1 Nef inhibits ASK1-dependent death signalling providing a potential mechanism for protecting the infected host cell.

Authors: R Geleziunas; W Xu; K Takeda; H Ichijo; W C Greene
Journal: Nature Date: 2001-04-12 Impact factor: 49.962

6. HIV-1 Nef protein protects infected primary cells against killing by cytotoxic T lymphocytes.

Authors: K L Collins; B K Chen; S A Kalams; B D Walker; D Baltimore
Journal: Nature Date: 1998-01-22 Impact factor: 49.962

7. Human immunodeficiency virus type 1 Nef binds to tumor suppressor p53 and protects cells against p53-mediated apoptosis.

Authors: Alison L Greenway; Dale A McPhee; Kelly Allen; Ricky Johnstone; Gavan Holloway; John Mills; Ahmed Azad; Sonia Sankovich; Paul Lambert
Journal: J Virol Date: 2002-03 Impact factor: 5.103

8. Increasing the potency and breadth of an HIV antibody by using structure-based rational design.

Authors: Ron Diskin; Johannes F Scheid; Paola M Marcovecchio; Anthony P West; Florian Klein; Han Gao; Priyanthi N P Gnanapragasam; Alexander Abadir; Michael S Seaman; Michel C Nussenzweig; Pamela J Bjorkman
Journal: Science Date: 2011-10-27 Impact factor: 47.728

HIV-1 Nef: hacker of the host cell.

1. HIV-1 Nef associated PAK and PI3-kinases stimulate Akt-independent Bad-phosphorylation to induce anti-apoptotic signals.

Review 2. HIV-1 accessory proteins--ensuring viral survival in a hostile environment.

3. Dynamic evolution of the human immunodeficiency virus type 1 pathogenic factor, Nef.

4. Nef-mediated suppression of T cell activation was lost in a lentiviral lineage that gave rise to HIV-1.

5. HIV-1 Nef inhibits ASK1-dependent death signalling providing a potential mechanism for protecting the infected host cell.

6. HIV-1 Nef protein protects infected primary cells against killing by cytotoxic T lymphocytes.

7. Human immunodeficiency virus type 1 Nef binds to tumor suppressor p53 and protects cells against p53-mediated apoptosis.

8. Increasing the potency and breadth of an HIV antibody by using structure-based rational design.

9. HIV-1 Nef mediates lymphocyte chemotaxis and activation by infected macrophages.

10. HIV-1 Nef intersects the macrophage CD40L signalling pathway to promote resting-cell infection.

1. Modulation of HIV pathogenesis and T-cell signaling by HIV-1 Nef.

Review 2. Review of Current Cell-Penetrating Antibody Developments for HIV-1 Therapy.

3. HIV-1 Impairment via UBE3A and HIV-1 Nef Interactions Utilizing the Ubiquitin Proteasome System.