Antonio Capone1, Michael A Singer, David G Dodwell, Richard F Dreyer, Kean T Oh, Daniel B Roth, John G Walt, Lanita C Scott, David A Hollander. 1. *Associated Retinal Consultants, Novi, Michigan; †Department of Ophthalmology, Oakland University, William Beaumont Hospital School of Medicine, Rochester, Michigan; ‡Medical Center Ophthalmology Associates, San Antonio, Texas; §Illinois Retina Center, Springfield, Illinois; ¶Retina Northwest PC, Portland, Oregon; **Associated Retinal Consultants, Traverse City, Michigan; ††Retina-Vitreous Center, UMDNJ-Robert Wood Johnson Medical School, New Brunswick, New Jersey; ‡‡Allergan, Inc, Irvine, California.
Abstract
PURPOSE: To evaluate the efficacy, safety, and reinjection interval of dexamethasone intravitreal implant (DEX implant) in branch retinal vein occlusion and central retinal vein occlusion patients receiving ≥ 2 DEX implant treatments. METHODS: Multicenter (26-site), retrospective chart review study. Data were collected from baseline (at first DEX implant) through 3 months to 6 months after last DEX implant. RESULTS:Patients (n = 289) received 2 to 9 (mean, 3.2) DEX implants as monotherapy (29.1% of patients) or with adjunctive treatments/procedures. Mean duration of macular edema before first DEX implant was 18.4 months. Mean reinjection interval was 5.6 months. Mean peak change in best-corrected visual acuity from baseline through 4 weeks to 20 weeks after final DEX implant was +1.0 line (P < 0.001). Best-corrected visual acuity and central retinal thickness improved significantly from baseline after each of the first 6 DEX implant injections (P ≤ 0.037); 59.7% of branch retinal vein occlusion and 66.7% of central retinal vein occlusion patients achieved ≥ 2-line best-corrected visual acuity improvement. Intraocular pressure increase (≥ 10 mmHg) occurred in 32.6% of patients; 29.1% used intraocular pressure-lowering medication to treat increases associated with DEX implant. Only 1.7% of patients required incisional glaucoma surgery. CONCLUSION: Retinal vein occlusion patients treated with multiple DEX implant injections, either alone or combined with other therapies, had improved central retinal thickness and visual acuity with each subsequent injection. No new safety concerns developed with multiple implants.
RCT Entities:
PURPOSE: To evaluate the efficacy, safety, and reinjection interval of dexamethasone intravitreal implant (DEX implant) in branch retinal vein occlusion and central retinal vein occlusionpatients receiving ≥ 2 DEX implant treatments. METHODS: Multicenter (26-site), retrospective chart review study. Data were collected from baseline (at first DEX implant) through 3 months to 6 months after last DEX implant. RESULTS:Patients (n = 289) received 2 to 9 (mean, 3.2) DEX implants as monotherapy (29.1% of patients) or with adjunctive treatments/procedures. Mean duration of macular edema before first DEX implant was 18.4 months. Mean reinjection interval was 5.6 months. Mean peak change in best-corrected visual acuity from baseline through 4 weeks to 20 weeks after final DEX implant was +1.0 line (P < 0.001). Best-corrected visual acuity and central retinal thickness improved significantly from baseline after each of the first 6 DEX implant injections (P ≤ 0.037); 59.7% of branch retinal vein occlusion and 66.7% of central retinal vein occlusionpatients achieved ≥ 2-line best-corrected visual acuity improvement. Intraocular pressure increase (≥ 10 mmHg) occurred in 32.6% of patients; 29.1% used intraocular pressure-lowering medication to treat increases associated with DEX implant. Only 1.7% of patients required incisional glaucoma surgery. CONCLUSION:Retinal vein occlusionpatients treated with multiple DEX implant injections, either alone or combined with other therapies, had improved central retinal thickness and visual acuity with each subsequent injection. No new safety concerns developed with multiple implants.
Authors: Sofia Theodoropoulou; Abdallah A Ellabban; Robert L Johnston; Helena Cilliers; Quresh Mohamed; Ahmed B Sallam Journal: Graefes Arch Clin Exp Ophthalmol Date: 2016-11-22 Impact factor: 3.117
Authors: Wai-Ching Lam; David A Albiani; Pradeepa Yoganathan; John Chanchiang Chen; Amin Kherani; David Al Maberley; Alejandro Oliver; Theodore Rabinovitch; Thomas G Sheidow; Eric Tourville; Leah A Wittenberg; Chris Sigouin; Darryl C Baptiste Journal: Clin Ophthalmol Date: 2015-07-10
Authors: Pravin U Dugel; Antonio Capone; Michael A Singer; Richard F Dreyer; David G Dodwell; Daniel B Roth; Rui Shi; John G Walt; Lanita C Scott; David A Hollander Journal: BMC Ophthalmol Date: 2015-09-04 Impact factor: 2.209