BACKGROUND/ PURPOSE: The aim of this study was to review evidence-based literature addressing pertinent questions about venous thromboembolism (VTE) after traumatic injury in children. METHODS: Data were obtained from English-language articles identified through Pubmed published from 1995 until November 2012, and from bibliographies of relevant articles. Studies were included if they contributed evidence to one of the following questions. In the pediatric traumatic injury population: (1) What is the overall incidence of VTE? (2) Is age (adolescence versus pre-adolescence) associated with higher VTE incidence? (3) Which risk factors are associated with higher VTE incidence? (4) Does mechanical and/or pharmacological prophylaxis impact outcomes? RESULTS: Eighteen articles were included in this systematic review. The evidence regarding each question was evaluated, graded by author consensus, and summarized. CONCLUSIONS: The overall incidence of VTE is low. Older (>13years) and more severely injured patients are at higher VTE risk. Additional factors including injury type or presence of a central venous catheter also place a patient at higher VTE risk. Implementation of a risk-based clinical practice guideline for VTE prophylaxis has been associated with reduced symptomatic VTE at one institution. Randomized, prospective trials analyzing outcomes of VTE prophylaxis in pediatric trauma victims are needed.
BACKGROUND/ PURPOSE: The aim of this study was to review evidence-based literature addressing pertinent questions about venous thromboembolism (VTE) after traumatic injury in children. METHODS: Data were obtained from English-language articles identified through Pubmed published from 1995 until November 2012, and from bibliographies of relevant articles. Studies were included if they contributed evidence to one of the following questions. In the pediatric traumatic injury population: (1) What is the overall incidence of VTE? (2) Is age (adolescence versus pre-adolescence) associated with higher VTE incidence? (3) Which risk factors are associated with higher VTE incidence? (4) Does mechanical and/or pharmacological prophylaxis impact outcomes? RESULTS: Eighteen articles were included in this systematic review. The evidence regarding each question was evaluated, graded by author consensus, and summarized. CONCLUSIONS: The overall incidence of VTE is low. Older (>13years) and more severely injured patients are at higher VTE risk. Additional factors including injury type or presence of a central venous catheter also place a patient at higher VTE risk. Implementation of a risk-based clinical practice guideline for VTE prophylaxis has been associated with reduced symptomatic VTE at one institution. Randomized, prospective trials analyzing outcomes of VTE prophylaxis in pediatric trauma victims are needed.
Authors: Mary Cushman; Geoffrey D Barnes; Mark A Creager; Jose A Diaz; Peter K Henke; Kellie R Machlus; Marvin T Nieman; Alisa S Wolberg Journal: Res Pract Thromb Haemost Date: 2020-07-08
Authors: Brandon A Sherrod; Samuel G McClugage; Vincent E Mortellaro; Inmaculada B Aban; Brandon G Rocque Journal: J Pediatr Surg Date: 2018-10-10 Impact factor: 2.545
Authors: Anthonie W A Lensing; Christoph Male; Guy Young; Dagmar Kubitza; Gili Kenet; M Patricia Massicotte; Anthony Chan; Angelo C Molinari; Ulrike Nowak-Goettl; Ákos F Pap; Ivet Adalbo; William T Smith; Amy Mason; Kirstin Thelen; Scott D Berkowitz; Mark Crowther; Stephan Schmidt; Victoria Price; Martin H Prins; Paul Monagle Journal: Thromb J Date: 2018-12-21