| Literature DB >> 23845538 |
Yael Yaniv1, Magdalena Juhaszova, Steven J Sollott.
Abstract
In advanced age, the resting myocardial oxygen consumption rate (MVO2) and cardiac work (CW) in the rat remain intact. However, MVO2, CW and cardiac efficiency achieved at high demand are decreased with age, compared to maximal values in the young. Whether this deterioration is due to decrease in myocardial ATP demand, ATP supply, or the control mechanisms that match them remains controversial. Here we discuss evolving perspectives of age-related changes of myocardial ATP supply and demand mechanisms, and critique experimental models used to investigate aging. Specifically, we evaluate experimental data collected at the level of isolated mitochondria, tissue, or organism, and discuss how mitochondrial energetic mechanisms change in advanced age, both at basal and high energy-demand levels. Published by Elsevier Ltd.Entities:
Keywords: aging; bioenergetics; cardiac work; mitochondria; respiration
Mesh:
Year: 2013 PMID: 23845538 PMCID: PMC3783621 DOI: 10.1016/j.tem.2013.06.001
Source DB: PubMed Journal: Trends Endocrinol Metab ISSN: 1043-2760 Impact factor: 12.015