Literature DB >> 23845538

Age-related changes of myocardial ATP supply and demand mechanisms.

Yael Yaniv1, Magdalena Juhaszova, Steven J Sollott.   

Abstract

In advanced age, the resting myocardial oxygen consumption rate (MVO2) and cardiac work (CW) in the rat remain intact. However, MVO2, CW and cardiac efficiency achieved at high demand are decreased with age, compared to maximal values in the young. Whether this deterioration is due to decrease in myocardial ATP demand, ATP supply, or the control mechanisms that match them remains controversial. Here we discuss evolving perspectives of age-related changes of myocardial ATP supply and demand mechanisms, and critique experimental models used to investigate aging. Specifically, we evaluate experimental data collected at the level of isolated mitochondria, tissue, or organism, and discuss how mitochondrial energetic mechanisms change in advanced age, both at basal and high energy-demand levels. Published by Elsevier Ltd.

Entities:  

Keywords:  aging; bioenergetics; cardiac work; mitochondria; respiration

Mesh:

Year:  2013        PMID: 23845538      PMCID: PMC3783621          DOI: 10.1016/j.tem.2013.06.001

Source DB:  PubMed          Journal:  Trends Endocrinol Metab        ISSN: 1043-2760            Impact factor:   12.015


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