PURPOSE: Heat shock protein 70 (HSPA family) is a multi-functional protein which protects individual cells from proteotoxic shock and the whole organism from microbial, viral and oncogenic pathogens. These diverse functions may depend upon 'chaperone' activity that allows Hsp70 to regulate the mechanism of damaged protein recovery or utilisation inside a cell and to be a potent adjuvant, stimulating immune activity against a variety of viral or tumour antigens. The aim of this review is to present recent data on specific roles of intracellular and extracellular Hsp70 in cancerous tissue. CONCLUSION: The data presented in this paper show that endogenous Hsp70 protects cancer cells of different origins from a variety of cytotoxic threats including cancer cell therapeutics. In contrast, however, Hsp70 released from stressed cancer cells can serve as a danger signal or may recruit cells responsible for the generation of innate and adaptive immune responses against tumour cells.
PURPOSE: Heat shock protein 70 (HSPA family) is a multi-functional protein which protects individual cells from proteotoxic shock and the whole organism from microbial, viral and oncogenic pathogens. These diverse functions may depend upon 'chaperone' activity that allows Hsp70 to regulate the mechanism of damaged protein recovery or utilisation inside a cell and to be a potent adjuvant, stimulating immune activity against a variety of viral or tumour antigens. The aim of this review is to present recent data on specific roles of intracellular and extracellular Hsp70 in cancerous tissue. CONCLUSION: The data presented in this paper show that endogenous Hsp70 protects cancer cells of different origins from a variety of cytotoxic threats including cancer cell therapeutics. In contrast, however, Hsp70 released from stressed cancer cells can serve as a danger signal or may recruit cells responsible for the generation of innate and adaptive immune responses against tumour cells.
Authors: Elena Y Komarova; Darya A Meshalkina; Nikolay D Aksenov; Ivan M Pchelin; Elena Martynova; Boris A Margulis; Irina V Guzhova Journal: Cell Stress Chaperones Date: 2014-11-12 Impact factor: 3.667
Authors: Maxim A Shevtsov; Elena Y Komarova; Darya A Meshalkina; Natalia V Bychkova; Nikolai D Aksenov; Sergey V Abkin; Boris A Margulis; Irina V Guzhova Journal: Oncotarget Date: 2014-05-30
Authors: Mateja Kralj Juric; Maxim Shevtsov; Petra Mozes; Justyna Ogonek; Rachel E Crossland; Anne M Dickinson; Hildegard T Greinix; Ernst Holler; Eva M Weissinger; Gabriele Multhoff Journal: Front Immunol Date: 2017-01-16 Impact factor: 7.561
Authors: Henryk M Kozłowski; Małgorzata Pawlikowska; Justyna Sobocińska; Tomasz Jędrzejewski; Artur Dzialuk; Sylwia Wrotek Journal: Pharmaceuticals (Basel) Date: 2021-06-08
Authors: Maxim A Shevtsov; Alexander V Kim; Konstantin A Samochernych; Irina V Romanova; Boris A Margulis; Irina V Guzhova; Igor V Yakovenko; Alexander M Ischenko; William A Khachatryan Journal: Onco Targets Ther Date: 2014-06-18 Impact factor: 4.147
Authors: Darya A Meshalkina; Maxim A Shevtsov; Anatoliy V Dobrodumov; Elena Y Komarova; Irina V Voronkina; Vladimir F Lazarev; Boris A Margulis; Irina V Guzhova Journal: Oncotarget Date: 2016-04-19