| Literature DB >> 23844559 |
Abstract
In this paper we propose a semiparametric quantile regression model for censored survival data. Quantile regression permits covariates to affect survival differently at different stages in the follow-up period, thus providing a comprehensive study of the survival distribution. We take a semiparametric approach, representing the quantile process as a linear combination of basis functions. The basis functions are chosen so that the prior for the quantile process is centered on a simple location-scale model, but flexible enough to accommodate a wide range of quantile processes. We show in a simulation study that this approach is competitive with existing methods. The method is illustrated using data from a drug treatment study, where we find that the Bayesian model often gives smaller measures of uncertainty than its competitors, and thus identifies more significant effects.Keywords: Accelerated failure time model; Markov chain Monte Carlo; Quantile regression; Survival data
Mesh:
Year: 2013 PMID: 23844559 DOI: 10.1111/biom.12053
Source DB: PubMed Journal: Biometrics ISSN: 0006-341X Impact factor: 2.571