OBJECTIVE: An obesity risk allele at the NEGR1 locus was shown to be associated with weight regain after a lifestyle intervention in obese adults. Independent confirmation and studies in children are lacking. Therefore, we analyzed the impact of this and 11 additional obesity susceptibility loci on weight regain after a lifestyle intervention in overweight children. DESIGN AND METHODS: We longitudinally analyzed the changes in weight status as body mass index standard deviation score (BMI-SDS) in 282 overweight children (10.6 ± 2.5 years, 47% male, BMI 27.1 ± 3.9 kg/m2) both at the end of a 1-year lifestyle intervention and at 1 year after the end of intervention. We genotyped obesity risk single nucleotide polymorphisms (SNPs) derived from genome-wide association studies in or in proximity to the following genes: NEGR1, TNKS, SDCCAG8, FTO, MC4R, TMEM18, PTER, MTCH2, SH2B1, MAF, NPC1, and KCTD15. RESULTS: The children reduced their BMI-SDS (-0.28 ± 0.35; p<0.001) during intervention and increased their BMI-SDS between the end of intervention and 1 year later (+0.05 ± 0.36; p=0.027). None of the SNPs including NEGR1 was related significantly to weight regain. CONCLUSIONS: We found no evidence for effects of any of the GWAS-based obesity marker alleles on weight regain in the course of 1 year after an intervention.
OBJECTIVE: An obesity risk allele at the NEGR1 locus was shown to be associated with weight regain after a lifestyle intervention in obese adults. Independent confirmation and studies in children are lacking. Therefore, we analyzed the impact of this and 11 additional obesity susceptibility loci on weight regain after a lifestyle intervention in overweight children. DESIGN AND METHODS: We longitudinally analyzed the changes in weight status as body mass index standard deviation score (BMI-SDS) in 282 overweight children (10.6 ± 2.5 years, 47% male, BMI 27.1 ± 3.9 kg/m2) both at the end of a 1-year lifestyle intervention and at 1 year after the end of intervention. We genotyped obesity risk single nucleotide polymorphisms (SNPs) derived from genome-wide association studies in or in proximity to the following genes: NEGR1, TNKS, SDCCAG8, FTO, MC4R, TMEM18, PTER, MTCH2, SH2B1, MAF, NPC1, and KCTD15. RESULTS: The children reduced their BMI-SDS (-0.28 ± 0.35; p<0.001) during intervention and increased their BMI-SDS between the end of intervention and 1 year later (+0.05 ± 0.36; p=0.027). None of the SNPs including NEGR1 was related significantly to weight regain. CONCLUSIONS: We found no evidence for effects of any of the GWAS-based obesity marker alleles on weight regain in the course of 1 year after an intervention.
Authors: Melanie Heitkamp; Monika Siegrist; Sophie Molnos; Stefan Brandmaier; Simone Wahl; Helmut Langhof; Harald Grallert; Martin Halle Journal: JAMA Pediatr Date: 2021-01-04 Impact factor: 16.193
Authors: Anna-Lena Volckmar; Chung Ting Han; Carolin Pütter; Stefan Haas; Carla I G Vogel; Nadja Knoll; Christoph Struve; Maria Göbel; Katharina Haas; Nikolas Herrfurth; Ivonne Jarick; Harald Grallert; Annette Schürmann; Hadi Al-Hasani; Johannes Hebebrand; Sascha Sauer; Anke Hinney Journal: PLoS One Date: 2016-02-01 Impact factor: 3.240
Authors: Lukas Zlatohlavek; Vit Maratka; Eva Tumova; Richard Ceska; Vera Lanska; Michal Vrablik; Jaroslav A Hubacek Journal: Med Sci Monit Date: 2018-10-20