Literature DB >> 23843418

Orbital apex tumour caused by chronic lymphocytic leukaemia: an unlikely suspect.

Kanai Garala1, Pavitra Jayaramachandran, Michael Knopp, Peter Critchley.   

Abstract

An 88-year-old woman with a background of chronic lymphocytic leukaemia (CLL) and presented with unilateral ptosis and dull facial pains for 1 month. Examination revealed a complete right-sided ptosis and pupillary dilation. Vision in her right eye was limited to light perception. She had total external ophthalmoplegia. Her corneal reflex was not present in her right eye and she had lost sensation on the right side of her forehead. MRI revealed abnormal enhancement in the right orbital apex extending posteriorly to the sphenoid sinus. The mass invaded the superior orbital fissure, optic canal and cavernous sinus. The lumbar puncture was normal. Owing to the proximity of the mass to the cavernous sinus, it was deemed that surgical excision of the tumour was unsafe; however, it was amenable to biopsy. Histology of the biopsies was consistent with CLL. The patient declined to undergo single high-dose radiotherapy followed by dexamethasone.

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Mesh:

Year:  2013        PMID: 23843418      PMCID: PMC3736671          DOI: 10.1136/bcr-2013-200166

Source DB:  PubMed          Journal:  BMJ Case Rep        ISSN: 1757-790X


  5 in total

1.  Facial nerve paresis as the presenting symptom of leukemia.

Authors:  J J Zappia; F A Bunge; C F Koopmann; K D McClatchey
Journal:  Int J Pediatr Otorhinolaryngol       Date:  1990-08       Impact factor: 1.675

2.  Leptomeningeal disease in chronic lymphocytic leukemia.

Authors:  C P E Lange; R E Brouwer; R Brooimans; Ch J Vecht
Journal:  Clin Neurol Neurosurg       Date:  2007-09-12       Impact factor: 1.876

3.  Sudden onset deafness as a presenting manifestation of chronic lymphocytic leukemia.

Authors:  B Nageris; R Or; I Hardan; A Polliack
Journal:  Leuk Lymphoma       Date:  1993-02

Review 4.  Chronic lymphocytic leukemia and the central nervous system: a clinical and pathological study.

Authors:  S C Cramer; J A Glaspy; J T Efird; D N Louis
Journal:  Neurology       Date:  1996-01       Impact factor: 9.910

5.  Chronic lymphocytic leukemia presenting with symptomatic central nervous system involvement.

Authors:  O Akintola-Ogunremi; C Whitney; S C Mathur; C N Finch
Journal:  Ann Hematol       Date:  2002-06-13       Impact factor: 3.673

  5 in total
  1 in total

Review 1.  Orbital Apex Syndrome: A Review.

Authors:  Akshay Badakere; Preeti Patil-Chhablani
Journal:  Eye Brain       Date:  2019-12-12
  1 in total

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