| Literature DB >> 23843347 |
Olga N Zefirova1, Heiko Lemcke, Margareta Lantow, Evgeniya V Nurieva, Birgit Wobith, Galina E Onishchenko, Antje Hoenen, Gareth Griffiths, Nikolay S Zefirov, Sergei A Kuznetsov.
Abstract
Highly cytotoxic C7-modified colchicine analogues, exemplified by tubuloclustin, promote microtubule disassembly followed by the formation of very stable tubulin clusters, both in vitro and in cells. The proposed mechanism of action of tubuloclustin and its analogues, beyond that of colchicine, includes additional specific interactions with the α-tubulin subunit.Entities:
Keywords: anticancer agents; apoptosis; colchicine; cytotoxicity; microtubules; tubulin
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Year: 2013 PMID： 23843347 DOI： 10.1002/cbic.201300143
Source DB: PubMed Journal: Chembiochem ISSN： 1439-4227 Impact factor: 3.164