Literature DB >> 23843286

Cyplecksins are covalent inhibitors of the pleckstrin homology domain of cytohesin.

Mohamed Hussein1, Martina Bettio, Anton Schmitz, Jeffrey S Hannam, Julian Theis, Günter Mayer, Stefan Dosa, Michael Gütschow, Michael Famulok.   

Abstract

Keywords:  Cyplecksins; aptamers; cytohesin; drug development; inhibitors

Mesh：

Substances：

Year:  2013        PMID： 23843286     DOI： 10.1002/anie.201302207

Source DB:  PubMed          Journal:  Angew Chem Int Ed Engl        ISSN： 1433-7851            Impact factor:   15.336


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  4 in total

1.  Insights into the inhibitory mechanism of triazole-based small molecules on phosphatidylinositol-4,5-bisphosphate binding pleckstrin homology domain.

Authors:  Sukhamoy Gorai; Prasanta Ray Bagdi; Rituparna Borah; Debasish Paul; Manas Kumar Santra; Abu Taleb Khan; Debasis Manna
Journal:  Biochem Biophys Rep       Date:  2015-05-27

2.  Identification of a small molecule inhibitor that stalls splicing at an early step of spliceosome activation.

Authors:  Anzhalika Sidarovich; Cindy L Will; Maria M Anokhina; Javier Ceballos; Sonja Sievers; Dmitry E Agafonov; Timur Samatov; Penghui Bao; Berthold Kastner; Henning Urlaub; Herbert Waldmann; Reinhard Lührmann
Journal:  Elife       Date:  2017-03-16       Impact factor: 8.140

3.  Systematic simulation of the interactions of pleckstrin homology domains with membranes.

Authors:  Kyle I P Le Huray; He Wang; Frank Sobott; Antreas C Kalli
Journal:  Sci Adv       Date:  2022-07-06       Impact factor: 14.957

4.  An Automated Microscale Thermophoresis Screening Approach for Fragment-Based Lead Discovery.

Authors:  Pawel Linke; Kwame Amaning; Melanie Maschberger; Francois Vallee; Valerie Steier; Philipp Baaske; Stefan Duhr; Dennis Breitsprecher; Alexey Rak
Journal:  J Biomol Screen       Date:  2015-12-02
  4 in total

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