PURPOSE OF REVIEW: Selective lipid uptake (SLU) is known to be a major pathway of lipoprotein cholesterol metabolism in experimental animals and humans, but remains poorly understood. This review provides a brief overview of SLU mediated by the HDL receptor scavenger receptor B-type I (SR-BI), and highlights several surprising new findings related to the impact of SLU pathways in cholesterol homeostasis. RECENT FINDINGS: Under certain conditions, SR-BI-mediated SLU contributes to reverse cholesterol transport (RCT) independently of ABCG5/G8-mediated biliary cholesterol secretion, implying a novel trafficking mechanism. Hepatic SR-BI expression and RCT are decreased in diabetic mice. Farnesoid X receptor (FXR) and the microRNAs miR-185, miR-96 and miR-223 are emerging therapeutic targets for increasing SR-BI expression. SR-BI-independent selective cholesteryl ester uptake is a newly characterized pathway in macrophage foam cells. SUMMARY: New findings underscore the importance of SR-BI-mediated SLU in hepatic SLU and RCT, while indicating that further investigation is needed to define SLU pathways, including SR-BI-independent macrophage selective cholesteryl ester uptake. The intracellular trafficking of cholesterol in these pathways appears to be critical to their normal function and is a major subject of ongoing studies.
PURPOSE OF REVIEW: Selective lipid uptake (SLU) is known to be a major pathway of lipoprotein cholesterol metabolism in experimental animals and humans, but remains poorly understood. This review provides a brief overview of SLU mediated by the HDL receptor scavenger receptor B-type I (SR-BI), and highlights several surprising new findings related to the impact of SLU pathways in cholesterol homeostasis. RECENT FINDINGS: Under certain conditions, SR-BI-mediated SLU contributes to reverse cholesterol transport (RCT) independently of ABCG5/G8-mediated biliary cholesterol secretion, implying a novel trafficking mechanism. Hepatic SR-BI expression and RCT are decreased in diabeticmice. Farnesoid X receptor (FXR) and the microRNAs miR-185, miR-96 and miR-223 are emerging therapeutic targets for increasing SR-BI expression. SR-BI-independent selective cholesteryl ester uptake is a newly characterized pathway in macrophage foam cells. SUMMARY: New findings underscore the importance of SR-BI-mediated SLU in hepatic SLU and RCT, while indicating that further investigation is needed to define SLU pathways, including SR-BI-independent macrophage selective cholesteryl ester uptake. The intracellular trafficking of cholesterol in these pathways appears to be critical to their normal function and is a major subject of ongoing studies.
Authors: Jan Freark de Boer; Wijtske Annema; Marijke Schreurs; Jelske N van der Veen; Markus van der Giet; Niels Nijstad; Folkert Kuipers; Uwe J F Tietge Journal: J Lipid Res Date: 2011-12-18 Impact factor: 5.922
Authors: Robert S Rosenson; H Bryan Brewer; W Sean Davidson; Zahi A Fayad; Valentin Fuster; James Goldstein; Marc Hellerstein; Xian-Cheng Jiang; Michael C Phillips; Daniel J Rader; Alan T Remaley; George H Rothblat; Alan R Tall; Laurent Yvan-Charvet Journal: Circulation Date: 2012-04-17 Impact factor: 29.690
Authors: Jonathan C Cruz; Matthew Thomas; Edmund Wong; Nobutaka Ohgami; Shigeki Sugii; Thomas Curphey; Catherine C Y Chang; Ta-Yuan Chang Journal: J Lipid Res Date: 2002-08 Impact factor: 5.922
Authors: Muhammad N Zahid; Marine Turek; Fei Xiao; Viet Loan Dao Thi; Maryse Guérin; Isabel Fofana; Philippe Bachellier; John Thompson; Leen Delang; Johan Neyts; Dorothea Bankwitz; Thomas Pietschmann; Marlène Dreux; François-Loïc Cosset; Fritz Grunert; Thomas F Baumert; Mirjam B Zeisel Journal: Hepatology Date: 2012-12-28 Impact factor: 17.425