Literature DB >> 2384173

Molecular cloning and functional expression of a potassium channel cDNA isolated from a rat cardiac library.

J C Tseng-Crank1, G N Tseng, A Schwartz, M A Tanouye.   

Abstract

A full-length K+ channel cDNA (RHK1) was isolated from a rat cardiac library using the polymerase chain reaction (PCR) method and degenerate oligonucleotide primers derived from K+ channel sequences conserved between Drosophila Shaker H4 and mouse brain MBK1. Although RHK1 was isolated from heart, its expression was found in both heart and brain. The RHK1-encoded protein, when expressed in Xenopus oocytes, gated a 4-aminopyridine (4-AP)-sensitive transient outward current. This current is similar to the transient outward current measured in rat ventricular myocytes with respect to voltage-dependence of activation and inactivation, time course of activation and inactivation, and pharmacology.

Entities:  

Mesh：

Substances：

Year:  1990        PMID： 2384173     DOI： 10.1016/0014-5793(90)80973-m

Source DB:  PubMed          Journal:  FEBS Lett        ISSN： 0014-5793            Impact factor:   4.124


  41 in total

Review 1.  Molecular basis of functional voltage-gated K+ channel diversity in the mammalian myocardium.

Authors:  J M Nerbonne
Journal:  J Physiol       Date:  2000-06-01       Impact factor: 5.182

2.  Molecular determinants of emerging excitability in rat embryonic motoneurons.

Authors:  Nicole Alessandri-Haber; Giséle Alcaraz; Charlotte Deleuze; Florence Jullien; Christine Manrique; François Couraud; Marcel Crest; Pierre Giraud
Journal:  J Physiol       Date:  2002-05-15       Impact factor: 5.182

3.  Molecular correlates of the calcium-independent, depolarization-activated K+ currents in rat atrial myocytes.

Authors:  E Bou-Abboud; J M Nerbonne
Journal:  J Physiol       Date:  1999-06-01       Impact factor: 5.182

4.  Relationship between K+ channel down-regulation and [Ca2+]i in rat ventricular myocytes following myocardial infarction.

Authors:  R Kaprielian; A D Wickenden; Z Kassiri; T G Parker; P P Liu; P H Backx
Journal:  J Physiol       Date:  1999-05-15       Impact factor: 5.182

5.  KCNE2 protein is more abundant in ventricles than in atria and can accelerate hERG protein degradation in a phosphorylation-dependent manner.

Authors:  Mei Zhang; Yuhong Wang; Min Jiang; Dimitar P Zankov; Sabeeha Chowdhury; Vigneshwar Kasirajan; Gea-Ny Tseng
Journal:  Am J Physiol Heart Circ Physiol       Date:  2011-12-16       Impact factor: 4.733

Review 6.  At the heart of computational modelling.

Authors:  S A Niederer; N P Smith
Journal:  J Physiol       Date:  2012-01-23       Impact factor: 5.182

7.  mShal, a subfamily of A-type K+ channel cloned from mammalian brain.

Authors:  M D Pak; K Baker; M Covarrubias; A Butler; A Ratcliffe; L Salkoff
Journal:  Proc Natl Acad Sci U S A       Date:  1991-05-15       Impact factor: 11.205

Review 8.  Transient outward potassium current, 'Ito', phenotypes in the mammalian left ventricle: underlying molecular, cellular and biophysical mechanisms.

Authors:  Sangita P Patel; Donald L Campbell
Journal:  J Physiol       Date:  2005-04-14       Impact factor: 5.182

9.  Expression and biophysical properties of Kv1 channels in supragranular neocortical pyramidal neurones.

Authors:  D Guan; J C F Lee; T Tkatch; D J Surmeier; W E Armstrong; R C Foehring
Journal:  J Physiol       Date:  2005-12-22       Impact factor: 5.182

Review 10.  Oxidative modulation of voltage-gated potassium channels.

Authors:  Nirakar Sahoo; Toshinori Hoshi; Stefan H Heinemann
Journal:  Antioxid Redox Signal       Date:  2013-10-26       Impact factor: 8.401
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.