MicroRNA-mediated autophagic signaling networks and cancer chemoresistance.

Chemoresistance remains a major clinical obstacle to successful cancer treatment and brings about poor prognosis of the patients, yet the underlying mechanisms have not been entirely understood. MicroRNAs (miRNAs) are a new class of small noncoding RNAs that may play an essential role for regulation of programmed cell death, which consists of apoptosis and autophagy. Autophagy refers to an evolutionarily conserved catabolic process in which, a cell degrades long-lived proteins and damaged organelles. Recently, increasing evidence indicates that autophagy is associated with multiple cancer-related pathways, including resistance to chemotherapeutics. Moreover, manipulation of miRNA expression levels may increase cell sensitivity to cytotoxic drugs through targeting the autophagic signaling pathway. In this review, we summarized the recent findings concerning miRNAs involved in autophagy, mainly focused on the mechanism of miRNA modulation at different autophagic stages, the crucial role of miRNAs in the interconnection between autophagy and apoptosis, and the potential of miRNAs to overcome chemoresistance by targeting autophagic pathways.