Literature DB >> 23841701

Naphthyridinomycin biosynthesis revealing the use of leader peptide to guide nonribosomal peptide assembly.

Jin-Yue Pu1, Chao Peng, Man-Cheng Tang, Yue Zhang, Jian-Ping Guo, Li-Qiang Song, Qiang Hua, Gong-Li Tang.   

Abstract

Analysis of naphthyridinomycin gene cluster revealed that this antibiotic is generated by nonribosomal peptide synthetase (NRPS) machinery. However, four modules encoded by two genes do not correspond with the structural units in the final product. Genetic and biochemical characterization of the gene cluster suggested that the leader peptide mechanism for the NRPS assembly line was involved in biosynthesis of this tetrahydroisoquinoline alkaloid.

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Year:  2013        PMID： 23841701     DOI： 10.1021/ol401549y

Source DB:  PubMed          Journal:  Org Lett        ISSN： 1523-7052            Impact factor:   6.005


  10 in total

Review 1.  Genetic manipulation of secondary metabolite biosynthesis for improved production in Streptomyces and other actinomycetes.

Authors:  Richard H Baltz
Journal:  J Ind Microbiol Biotechnol       Date:  2015-09-12       Impact factor: 3.346

2.  α-Amine Desaturation of d-Arginine by the Iron(II)- and 2-(Oxo)glutarate-Dependent l-Arginine 3-Hydroxylase, VioC.

Authors:  Noah P Dunham; Andrew J Mitchell; José M Del Río Pantoja; Carsten Krebs; J Martin Bollinger; Amie K Boal
Journal:  Biochemistry       Date:  2018-11-07       Impact factor: 3.162

3.  Extracellularly oxidative activation and inactivation of matured prodrug for cryptic self-resistance in naphthyridinomycin biosynthesis.

Authors:  Yue Zhang; Wan-Hong Wen; Jin-Yue Pu; Man-Cheng Tang; Liwen Zhang; Chao Peng; Yuquan Xu; Gong-Li Tang
Journal:  Proc Natl Acad Sci U S A       Date:  2018-10-16       Impact factor: 11.205

Review 4.  Natural products from thioester reductase containing biosynthetic pathways.

Authors:  Michael W Mullowney; Ryan A McClure; Matthew T Robey; Neil L Kelleher; Regan J Thomson
Journal:  Nat Prod Rep       Date:  2018-09-19       Impact factor: 13.423

Review 5.  Potent Antibiotic Lemonomycin: A Glimpse of Its Discovery, Origin, and Chemical Synthesis.

Authors:  Shunan Tao; Yang Wang; Ran Hong; Sha-Hua Huang
Journal:  Molecules       Date:  2022-07-05       Impact factor: 4.927

6.  Complete Genome Sequence of Streptomyces sp. Strain BSE7F, a Bali Mangrove Sediment Actinobacterium with Antimicrobial Activities.

Authors:  Ira Handayani; Shanti Ratnakomala; Puspita Lisdiyanti; Mohammad Alanjary; Wolfgang Wohlleben; Yvonne Mast
Journal:  Genome Announc       Date:  2018-06-28

7.  Investigation of Streptomyces sp. Strain EMB24 Secondary Metabolite Profile Has Unraveled Its Extraordinary Antibacterial Potency Against Drug-Resistant Bacteria.

Authors:  Nikky Goel; Rajendra Singh; Seema Sood; Sunil Kumar Khare
Journal:  Mar Biotechnol (NY)       Date:  2022-10-11       Impact factor: 3.727

8.  p-Aminophenylalanine Involved in the Biosynthesis of Antitumor Dnacin B1 for Quinone Moiety Formation.

Authors:  Xiaojing Hu; Xing Li; Yong Sheng; Hengyu Wang; Xiaobin Li; Yixin Ou; Zixin Deng; Linquan Bai; Qianjin Kang
Journal:  Molecules       Date:  2020-09-12       Impact factor: 4.411

9.  Reductive inactivation of the hemiaminal pharmacophore for resistance against tetrahydroisoquinoline antibiotics.

Authors:  Wan-Hong Wen; Yue Zhang; Ying-Ying Zhang; Qian Yu; Chu-Chu Jiang; Man-Cheng Tang; Jin-Yue Pu; Lian Wu; Yi-Lei Zhao; Ting Shi; Jiahai Zhou; Gong-Li Tang
Journal:  Nat Commun       Date:  2021-12-06       Impact factor: 14.919

Review 10.  Nonribosomal Peptide Synthesis Definitely Working Out of the Rules.

Authors:  Matthieu Duban; Stéphane Cociancich; Valérie Leclère
Journal:  Microorganisms       Date:  2022-03-07
  10 in total

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