Literature DB >> 2384159

Arachidonic acid epoxygenase. Stereochemical analysis of the endogenous epoxyeicosatrienoic acids of human kidney cortex.

A Karara1, E Dishman, H Jacobson, J R Falck, J H Capdevila.   

Abstract

Mass spectral and chromatographic analysis demonstrates the presence of 14,15-, 11,12- and 8,9-epoxyeicosatrienoic acids (44%, 33% and 23% of the total, respectively) in human kidney cortex. Chiral analysis of the human renal epoxyeicosatrienoic acids shows the formation of 8,9-, 11,12- and 14,15-epoxyeicosatrienoic acids in a 1:1, 4:1 and 2:1 ratio of antipodes, respectively. These results demonstrate the biosynthetic origin of the human kidney 11,12- and 14,15-epoxyeicosatrienoic acids and suggest a role for renal cytochrome P-450 in the bioactivation of endogenous pools of arachidonic acid.

Entities:  

Mesh：

Substances：

Year:  1990        PMID： 2384159     DOI： 10.1016/0014-5793(90)81014-f

Source DB:  PubMed          Journal:  FEBS Lett        ISSN： 0014-5793            Impact factor:   4.124


  14 in total

1.  Analysis of epoxyeicosatrienoic acids by chiral liquid chromatography/electron capture atmospheric pressure chemical ionization mass spectrometry using [13C]-analog internal standards.

Authors:  Clementina Mesaros; Seon Hwa Lee; Ian A Blair
Journal:  Rapid Commun Mass Spectrom       Date:  2010-11-30       Impact factor: 2.419

2.  P-450-dependent epoxygenase pathway of arachidonic acid is involved in myeloma-induced angiogenesis of endothelial cells.

Authors:  Jing Shao; Qiubai Li; Hongxiang Wang; Fang Liu; Jiangang Jiang; Xiaojian Zhu; Zhichao Chen; Ping Zou
Journal:  J Huazhong Univ Sci Technolog Med Sci       Date:  2011-10-25

Review 3.  Bisallylic hydroxylation and epoxidation of polyunsaturated fatty acids by cytochrome P450.

Authors:  E H Oliw; J Bylund; C Herman
Journal:  Lipids       Date:  1996-10       Impact factor: 1.880

4.  Epoxyeicosatrienoic acids and soluble epoxide hydrolase: potential therapeutic targets for inflammation and its induced carcinogenesis.

Authors:  Stephanie Norwood; Jie Liao; Bruce D Hammock; Guang-Yu Yang
Journal:  Am J Transl Res       Date:  2010-07-22       Impact factor: 4.060

Review 5.  Epoxygenase metabolites. Epithelial and vascular actions.

Authors:  J D Imig
Journal:  Mol Biotechnol       Date:  2000-11       Impact factor: 2.695

6.  Stereoselective epoxidation of the last double bond of polyunsaturated fatty acids by human cytochromes P450.

Authors:  Danièle Lucas; Sophie Goulitquer; Jan Marienhagen; Maude Fer; Yvonne Dreano; Ulrich Schwaneberg; Yolande Amet; Laurent Corcos
Journal:  J Lipid Res       Date:  2009-11-25       Impact factor: 5.922

Review 7.  The renal cytochrome P-450 arachidonic acid system.

Authors:  M Laniado-Schwartzman; N G Abraham
Journal:  Pediatr Nephrol       Date:  1992-09       Impact factor: 3.714

8.  Insulin resistance and endothelial dysfunction: Are epoxyeicosatrienoic acids the link?

Authors:  Sally Mustafa; Vijay Sharma; John H McNeill
Journal:  Exp Clin Cardiol       Date:  2009

Review 9.  Renal drug metabolism in humans: the potential for drug-endobiotic interactions involving cytochrome P450 (CYP) and UDP-glucuronosyltransferase (UGT).

Authors:  Kathleen M Knights; Andrew Rowland; John O Miners
Journal:  Br J Clin Pharmacol       Date:  2013-10       Impact factor: 4.335

10.  Targeted chiral analysis of bioactive arachidonic Acid metabolites using liquid-chromatography-mass spectrometry.

Authors:  Clementina Mesaros; Ian A Blair
Journal:  Metabolites       Date:  2012-04-20
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.