Literature DB >> 2384150

Molecular cloning and sequence analysis of cDNA encoding human cholesterol 7 alpha-hydroxylase.

M Noshiro1, K Okuda.   

Abstract

A complete cDNA clone encoding human cholesterol 7 alpha-hydroxylase has been isolated using a rat P-450ch7 alpha cDNA insert [(1989) FEBS Lett. 257, 97-100] as a probe and totally sequenced. The cDNA contained 1512-base pair open reading frame encoding 504 amino acid residues (Mr 57,630), 39-base pair 5'-untranslated region 1322-base pair 3'-ultranslated region including 20 nucleotides of poly A tail in the total length of 2873 base pairs. The deduced amino acid sequence showed 82% similarity to rat P-450ch7 alpha. Unique amino acid residues were observed in putative binding domains for heme and steroid which are highly conserved in most steroidogenic P-450s.

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Year:  1990        PMID： 2384150     DOI： 10.1016/0014-5793(90)80992-r

Source DB:  PubMed          Journal:  FEBS Lett        ISSN： 0014-5793            Impact factor:   4.124


  16 in total

1.  Synthesis and secretion of wild-type and mutant human plasma cholesteryl ester transfer protein in baculovirus-transfected insect cells: the carboxyl-terminal region is required for both lipoprotein binding and catalysis of transfer.

Authors:  J Au-Young; C J Fielding
Journal:  Proc Natl Acad Sci U S A       Date:  1992-05-01       Impact factor: 11.205

2.  Expression of human cholesterol 7alpha-hydroxylase in atherosclerosis-susceptible mice via adenovirus infection.

Authors:  G L Moore; C A Drevon; D Machleder; J D Trawick; A McClelland; S Roy; R Lyons; R Jambou; R A Davis
Journal:  Biochem J       Date:  1997-06-15       Impact factor: 3.857

3.  The 3'-untranslated region of the mouse cholesterol 7alpha-hydroxylase mRNA contains elements responsive to post-transcriptional regulation by bile acids.

Authors:  L B Agellon; S K Cheema
Journal:  Biochem J       Date:  1997-12-01       Impact factor: 3.857

4.  Cyp7b, a novel brain cytochrome P450, catalyzes the synthesis of neurosteroids 7alpha-hydroxy dehydroepiandrosterone and 7alpha-hydroxy pregnenolone.

Authors:  K A Rose; G Stapleton; K Dott; M P Kieny; R Best; M Schwarz; D W Russell; I Björkhem; J Seckl; R Lathe
Journal:  Proc Natl Acad Sci U S A       Date:  1997-05-13       Impact factor: 11.205

5.  Dietary cholesterol and downregulation of cholesterol 7 alpha-hydroxylase and cholesterol absorption in African green monkeys.

Authors:  L Rudel; C Deckelman; M Wilson; M Scobey; R Anderson
Journal:  J Clin Invest       Date:  1994-06       Impact factor: 14.808

6.  Regulation of hepatic 7 alpha-hydroxylase expression by dietary psyllium in the hamster.

Authors:  J D Horton; J A Cuthbert; D K Spady
Journal:  J Clin Invest       Date:  1994-05       Impact factor: 14.808

7.  Activation of the silent endogenous cholesterol-7-alpha-hydroxylase gene in rat hepatoma cells: a new complementation group having resistance to 25-hydroxycholesterol.

Authors:  J K Leighton; S Dueland; M S Straka; J Trawick; R A Davis
Journal:  Mol Cell Biol       Date:  1991-04       Impact factor: 4.272

8.  Comparative modeling of 25-hydroxycholesterol-7α-hydroxylase (CYP7B1): ligand binding and analysis of hereditary spastic paraplegia type 5 CYP7B1 mutations.

Authors:  Afraa Siam; Andrea Brancale; Claire Simons
Journal:  J Mol Model       Date:  2011-05-04       Impact factor: 1.810

Review 9.  Bile acids: regulation of synthesis.

Authors:  John Y L Chiang
Journal:  J Lipid Res       Date:  2009-04-03       Impact factor: 5.922

10.  Molecular basis of aromatase deficiency in an adult female with sexual infantilism and polycystic ovaries.

Authors:  Y Ito; C R Fisher; F A Conte; M M Grumbach; E R Simpson
Journal:  Proc Natl Acad Sci U S A       Date:  1993-12-15       Impact factor: 11.205
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