Literature DB >> 2384146

Exacerbation of rat adjuvant arthritis by intradermal injection of purified mammalian 14-kDa group II phospholipase A2.

M Murakami1, I Kudo, H Nakamura, Y Yokoyama, H Mori, K Inoue.   

Abstract

Appreciable phospholipase A2 activity was detected in a hind paw homogenate from rats with adjuvant arthritis or carrageenan-induced edema. The activity was neutralized by treatment with antibody raised against rat platelet secretory phospholipase A2, indicating that 14-kDa group II phospholipase A2 was induced in the hind paw during the process of inflammation. Injection of purified rat platelet phospholipase A2 into the hind paw of rats with adjuvant-induced arthritis resulted in exacerbation of edema in a dose-dependent manner, whereas no effect was observed on either normal rats or animals with carrageenan-induced edema under the same experimental conditions. These results suggest the importance of mammalian group II phospholipase A2 in the pathogenesis of some types of inflammation.

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Year:  1990        PMID： 2384146     DOI： 10.1016/0014-5793(90)80986-s

Source DB:  PubMed          Journal:  FEBS Lett        ISSN： 0014-5793            Impact factor:   4.124


  9 in total

1.  Posttranscriptional effect of insulin-like growth factor-I on interleukin-1beta-induced type II-secreted phospholipase A2 gene expression in rabbit articular chondrocytes.

Authors:  C Jacques; G Béréziat; L Humbert; J L Olivier; M T Corvol; J Masliah; F Berenbaum
Journal:  J Clin Invest       Date:  1997-04-15       Impact factor: 14.808

2.  Glucocorticoid deficiency increases phospholipase A2 activity in rats.

Authors:  B S Vishwanath; F J Frey; M J Bradbury; M F Dallman; B M Frey
Journal:  J Clin Invest       Date:  1993-10       Impact factor: 14.808

3.  Human recombinant platelet phospholipase A2 exacerbates poly-L-arginine induced rat paw edema.

Authors:  G Cirino; C Cicala; L Sorrentino
Journal:  Inflammation       Date:  1994-02       Impact factor: 4.092

4.  Design of group IIA secreted/synovial phospholipase A(2) inhibitors: an oxadiazolone derivative suppresses chondrocyte prostaglandin E(2) secretion.

Authors:  Jean-Edouard Ombetta; Natacha Thelier; Chang Zhi Dong; Stéphanie Plocki; Lydia Tsagris; François Rannou; France Massicot; Atimé Djimdé; Elissar El-Hayek; Yiming Shi; Françoise Heymans; Nohad Gresh; Caroline Chauvet
Journal:  PLoS One       Date:  2010-06-01       Impact factor: 3.240

5.  Cytokine-stimulated secretion of group II phospholipase A2 by rat mesangial cells. Its contribution to arachidonic acid release and prostaglandin synthesis by cultured rat glomerular cells.

Authors:  J Pfeilschifter; C Schalkwijk; V A Briner; H van den Bosch
Journal:  J Clin Invest       Date:  1993-11       Impact factor: 14.808

6.  Suppression of inflammatory responses to 12-O-tetradecanoyl-phorbol-13-acetate and carrageenin by YM-26734, a selective inhibitor of extracellular group II phospholipase A2.

Authors:  A Miyake; H Yamamoto; E Kubota; K Hamaguchi; A Kouda; K Honda; H Kawashima
Journal:  Br J Pharmacol       Date:  1993-09       Impact factor: 8.739

7.  Possible role of mammalian secretory group II phospholipase A2 in T-lymphocyte activation: implication in propagation of inflammatory reaction.

Authors:  Y Asaoka; K Yoshida; Y Sasaki; Y Nishizuka; M Murakami; I Kudo; K Inoue
Journal:  Proc Natl Acad Sci U S A       Date:  1993-01-15       Impact factor: 11.205

8.  Enhanced hydrolysis of phosphatidylcholine by human group II non-pancreatic secreted phospholipase A2 as a result of interfacial activation by specific anions. Potential role of cholesterol sulphate.

Authors:  A R Kinkaid; D C Wilton
Journal:  Biochem J       Date:  1995-06-01       Impact factor: 3.857

9.  Phospholipase A2 from plasma of patients with septic shock is associated with high-density lipoproteins and C3 anaphylatoxin: some implications for its functional role.

Authors:  M A Gijón; C Pérez; E Méndez; M Sánchez Crespo
Journal:  Biochem J       Date:  1995-02-15       Impact factor: 3.857
  9 in total

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