Literature DB >> 2384122

Demonstration of stereoselective disposition of warfarin enantiomers by whole-body autoradiography.

I Szinai1, M Simonyi, I Fitos, Z Tegyey, A Magyar.   

Abstract

The oral anticoagulant warfarin and its 14C-labelled derivative are commercially available in racemic forms. Two methods for the chromatographic resolution of the radiolabel were used to investigate the distribution of radioactivity of radioactivity of individual enantiomers in the rat by whole-body autoradiography. Computer-assisted quantification of autoradiograms indicated the average disappearance of levo-warfarin and its metabolites to be substantially slower than that of dextro-warfarin and its metabolites from the following organs: liver, pancreas, kidney, lung, blood, intestines.

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Year:  1990        PMID： 2384122     DOI： 10.1007/BF03190193

Source DB:  PubMed          Journal:  Eur J Drug Metab Pharmacokinet        ISSN： 0378-7966            Impact factor:   2.441


  7 in total

Review 1.  Signs of the times: the need for a stereochemically informative generic name system.

Authors:  M Simonyi; J Gal; B Testa
Journal:  Trends Pharmacol Sci       Date:  1989-09       Impact factor: 14.819

2.  Pharmacokinetics of the warfarin enantiomers in rats.

Authors:  A Yacobi; G Levy
Journal:  J Pharmacokinet Biopharm       Date:  1974-06

3.  Stereoselective binding of 3-acetoxy-, and 3-hydroxy-1,4-benzodiazepine-2-ones to human serum albumin. Selective allosteric interaction with warfarin enantiomers.

Authors:  I Fitos; Z Tegyey; M Simonyi; I Sjöholm; T Larsson; C Lagercrantz
Journal:  Biochem Pharmacol       Date:  1986-01-15       Impact factor: 5.858

Review 4.  On chiral drug action.

Authors:  M Simonyi
Journal:  Med Res Rev       Date:  1984 Jul-Sep       Impact factor: 12.944

5.  Binding of some fatty acids and drugs to immobilized bovine serum albumin studied by column affinity chromatography.

Authors:  C Lagercrantz; T Larsson; H Karlsson
Journal:  Anal Biochem       Date:  1979-11-01       Impact factor: 3.365

6.  Warfarin: stereochemical aspects of its metabolism in vivo in the rat.

Authors:  L R Pohl; R Bales; W F Trager
Journal:  Res Commun Chem Pathol Pharmacol       Date:  1976-10

7.  Stereoselective interaction between the R enantiomer of warfarin and cimetidine.

Authors:  I A Choonara; S Cholerton; B P Haynes; A M Breckenridge; B K Park
Journal:  Br J Clin Pharmacol       Date:  1986-03       Impact factor: 4.335
  7 in total
  1 in total

1.  Effect of the aluminium ion on hepatic elimination of quinine and quinidine.

Authors:  V Jakovljević; M Popović; A Sabo; B Banić
Journal:  Eur J Drug Metab Pharmacokinet       Date:  1995 Jul-Sep       Impact factor: 2.441
  1 in total

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