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Literature DB >> 23839610

What should I know before ordering a bone marrow aspiration/biopsy in patients with vitamin B12 deficiency?

Jaskirat Randhawa¹, Sarah L Ondrejka, Sebouh Setrakian, Harris Taylor.

Abstract

Vitamin B12 deficiency is a well recognised cause of macrocytic anaemia and bone marrow failure. Bone marrow aspiration/biopsy is infrequently indicated for the diagnosis in this setting. However, if a bone marrow aspiration/biopsy is performed, it is important to recognise that it may show dysplastic changes mimicking myelodysplastic syndrome (MDS) or acute leukaemia. We report a case of a 66-year-old non-vegetarian man presenting with generalised weakness for 1 month and misdiagnosed on bone marrow biopsy as MDS. However, laboratory investigations revealed severe deficiency of vitamin B12. Four weeks after starting vitamin B12 replacement the patient's complete blood counts reverted to normal.

Entities: Disease Gene Species

Mesh：

Year: 2013 PMID： 23839610 PMCID： PMC3736209 DOI： 10.1136/bcr-2013-010200

Source DB: PubMed Journal: BMJ Case Rep ISSN： 1757-790X

8 in total

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Review 8. The 2008 revision of the World Health Organization (WHO) classification of myeloid neoplasms and acute leukemia: rationale and important changes.

Authors: James W Vardiman; Jüergen Thiele; Daniel A Arber; Richard D Brunning; Michael J Borowitz; Anna Porwit; Nancy Lee Harris; Michelle M Le Beau; Eva Hellström-Lindberg; Ayalew Tefferi; Clara D Bloomfield
Journal: Blood Date: 2009-04-08 Impact factor: 22.113

8 in total

5 in total

Review 1. [Clinical hematological symptoms of vitamin B₁₂ deficiency in old age : Summarized overview of this year's symposium of the Working Group "Anemia in the Aged" on the occasion of the annual conference of the German Geriatric Society (DGG) in Frankfurt].

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Journal: Z Gerontol Geriatr Date: 2018-05-23 Impact factor: 1.281

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Authors: A H Leischker; G F Kolb
Journal: Z Gerontol Geriatr Date: 2015-01 Impact factor: 1.281

3. Vitamin B12 deficiency mimicking acute leukemia.

Authors: Manojna Konda; Abhijit Godbole; Soumya Pandey; Appalanaidu Sasapu
Journal: Proc (Bayl Univ Med Cent) Date: 2019-07-30

4. Hematological parameters and prevalence of anemia in white and British Indian vegetarians and nonvegetarians in the UK Biobank.

Authors: Tammy Y N Tong; Timothy J Key; Kezia Gaitskell; Timothy J Green; Wenji Guo; Thomas A Sanders; Kathryn E Bradbury
Journal: Am J Clin Nutr Date: 2019-08-01 Impact factor: 7.045

5. Vitamin B12 deficiency in northern India tertiary care: Prevalence, risk factors and clinical characteristics.

Authors: Jitendra Singh; Anju Dinkar; Poonam Gupta; Virendra Atam
Journal: J Family Med Prim Care Date: 2022-06-30

5 in total

Review 3. Clinical practice. Vitamin B12 deficiency.

Review 4. Dysplasia has A differential diagnosis: distinguishing genuine myelodysplastic syndromes (MDS) from mimics, imitators, copycats and impostors.

Review 8. The 2008 revision of the World Health Organization (WHO) classification of myeloid neoplasms and acute leukemia: rationale and important changes.

Review 1. [Clinical hematological symptoms of vitamin B12 deficiency in old age : Summarized overview of this year's symposium of the Working Group "Anemia in the Aged" on the occasion of the annual conference of the German Geriatric Society (DGG) in Frankfurt].

Review 1. [Clinical hematological symptoms of vitamin B₁₂ deficiency in old age : Summarized overview of this year's symposium of the Working Group "Anemia in the Aged" on the occasion of the annual conference of the German Geriatric Society (DGG) in Frankfurt].